Email this article THE CAUSES AND THE COURSE OF CHRONIC KIDNEY DISEASE IN CHILDREN OF PRESCHOOL AGE
- Authors: Abaseeva T.Y.1, Pankratenko T.E.1, Burov A.A.1, Emirova K.M.2, Muzurov A.L.3
-
Affiliations:
- Moscow Regional Research and Clinical Institute
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
- Russian Medical Academy of Postgraduate Education, Moscow
- Issue: No 42 (2015)
- Pages: 58-65
- Section: ARTICLES
- URL: https://almclinmed.ru/jour/article/view/21
- DOI: https://doi.org/10.18786/2072-0505-2015-42-58-65
- ID: 21
Cite item
Full Text
Abstract
Background: Data on etiology and clinical course of CKD stage 3 to 5 in children of preschool age could help obstetricians, pediatricians, and nephrologists with proper diagnostics and management of this condition and prediction of outcomes. Aim: To study causes and clinical features of CKD stage 3 to 5 in preschool children. Materials and methods: The causes and clinical features of CKD stage 3 to 5 were investigated in 55 preschool children aged from 7 months to 8 years. Twenty four had CKD stage 3 to 4 and 31 children with endstage CKD were on peritoneal dialysis. Results:96% of CKD stage 3 to 5 in preschool children were due to congenital/genetic kidney abnormalities. Predictors of renal replacement therapy beginning in the first 5 years of life were as follows: antenatal detection of congenital abnormalities of the kidney and urinary tract, oligohydroamnion, high neonatal BUN levels. Anemia, hyperparathyroidism, arterial hypertension were more prevalent in children on the dialysis stage of CKD, and myocardial hypertrophy and/or of the left ventricle dilatation were found in 26% of them. Forty two percent of children had growth retardation, and 40% had delayed speech development. Conclusion: The course CKD in preschool children is characterized by a combination of typical metabolic disorders with the growth retardation (often dramatic) and delayed mental development that significantly limits the possibilities of the social adaptation of these children and social activities of their parents. Participation of neuropsychiatrists, clinical psychologists, and teachers, rather than pediatricians and nephrologists only, is desirable in management of preschool children with CKD stage 3 to 5.
About the authors
T. Yu. Abaseeva
Moscow Regional Research and Clinical Institute
Author for correspondence.
Email: tatiana2103@inbox.ru
Abaseeva Tat'yana Yu. – PhD, Senior Research Fellow, Department of Pediatric Dialysis and Hemocorrection Russian Federation
T. E. Pankratenko
Moscow Regional Research and Clinical Institute
Email: tatiana2103@inbox.ru
Pankratenko Tat'yana E. – PhD, Head of Department of Pediatric Dialysis and Hemocorrection Russian Federation
A. A. Burov
Moscow Regional Research and Clinical Institute
Email: tatiana2103@inbox.ru
Burov Aleksandr A. – Research Fellow, Department of Pediatric Dialysis and Hemocorrection Russian Federation
Kh. M. Emirova
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Email: tatiana2103@inbox.ru
Emirova Khadizha M. – PhD, Associate Professor, Chair of Pediatrics Russian Federation
A. L. Muzurov
Russian Medical Academy of Postgraduate Education, Moscow
Email: tatiana2103@inbox.ru
Muzurov Aleksandr L. – PhD, Assistant Professor, Chair of Pediatric Anesthesiology, Resuscitation and Toxicology Russian Federation
References
- Harambat J, van Stralen KJ, Kim JJ, Tizard EJ.Epidemiology of chronic kidney disease inchildren. Pediatr Nephrol. 2012;27(3):363–73.doi: 10.1007/s00467-011-1939-1.
- Warady BA, Chadha V. Chronic kidney diseasein children: the global perspective. PediatrNephrol. 2007;22(12):1999–2009.
- Wong CJ, Moxey-Mims M, Jerry-Fluker J,Warady BA, Furth SL. CKiD (CKD in children)prospective cohort study: a review of currentfindings. Am J Kidney Dis. 2012;60(6):1002–11.doi: 10.1053/j.ajkd.2012.07.018.
- Hsu CW, Yamamoto KT, Henry RK, De Roos AJ,Flynn JT. Prenatal risk factors for childhoodCKD. J Am Soc Nephrol. 2014;25(9):2105–11.doi: 10.1681/ASN.2013060582.
- Mekahli D, Shaw V, Ledermann SE, Rees L.Long-term outcome of infants with severechronic kidney disease. Clin J Am Soc Nephrol.2010;5(1):10–7. doi: 10.2215/CJN.05600809.
- National Kidney Foundation. K/DOQI clinicalpractice guidelines for chronic kidney disease:evaluation, classification, and stratification.Am J Kidney Dis. 2002;39(2 Suppl 1):S1–266.
- McDonald SP, Craig JC; Australian and New ZealandPaediatricNephrologyAssociation.Longtermsurvivalofchildrenwithend-stagerenal
- disease.N Engl J Med.2004;350(26):2654–62. CKD. J Am Soc Nephrol. 2014;25(9):2105–11.doi: 10.1681/ASN.2013060582.
- Mekahli D, Shaw V, Ledermann SE, Rees L.Long-term outcome of infants with severechronic kidney disease. Clin J Am Soc Nephrol.2010;5(1):10–7. doi: 10.2215/CJN.05600809.
- National Kidney Foundation. K/DOQI clinicalpractice guidelines for chronic kidney disease:evaluation, classification, and stratification.Am J Kidney Dis. 2002;39(2 Suppl 1):S1–266.
- McDonald SP, Craig JC; Australian and New ZealandPaediatricNephrologyAssociation.Longtermsurvivalofchildrenwithend-stagerenaldisease.N Engl J Med.2004;350(26):2654–62.
- Baumgartner MR, Hörster F, Dionisi-Vici C,Haliloglu G, Karall D, Chapman KA, Huemer M,Hochuli M, Assoun M, Ballhausen D, Burlina A,Fowler B, Grünert SC, Grünewald S, Honzik T,Merinero B, Pérez-Cerdá C, Scholl-Bürgi S,Skovby F, Wijburg F, MacDonald A, Martinelli D,Sass JO,Valayannopoulos V,Chakrapani A.Proposedguidelines forthe diagnosisandmanagementof methylmalonicand propionicacidemia.OrphanetJ RareDis.2014;9:130. doi: 10.1186/s13023-014-0130-8.
- North American Pediatric Renal Trials and CollaborativeStudies:NAPRTCSannual report2006.Availablefrom:https://web.emmes. com/study/ped/annlpert/annlrept2006.pdf. Accessed June 15, 2009.
- Wedekin M, Ehrich JH, Offner G, Pape L. Renal replacement therapy in infants with chronic renal failure in the first year of life. Clin J Am Soc Nephrol. 2010;5(1):18–23. doi: 10.2215/ CJN.03670609.
- Zsengellér ZK, Aljinovic N, Teot LA, Korson M, Rodig N, Sloan JL, Venditti CP, Berry GT, Rosen S. Methylmalonicacidemia: a megamitochondrial disorder affecting the kidney. Pediatr Nephrol. 2014;29(11):2139–46. doi: 10.1007/ s00467-014-2847-y.
- Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; for HUS International. An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatr Nephrol. 2015Apr 11. [Epub ahead of print]
- Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D. Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest. 1991;64(6):777–84.
- Rodríguez MM, Gómez AH, Abitbol CL, Chandar JJ, Duara S, Zilleruelo GE. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol. 2004;7(1):17–25.
- Sutherland MR, Gubhaju L, Moore L, Kent AL, Dahlstrom JE, Horne RS, Hoy WE, Bertram JF, Black MJ. Accelerated maturation and abnormal morphology in the preterm neonatal kid ney. J Am Soc Nephrol. 2011;22(7):1365–74. doi: 10.1681/ASN.2010121266.
- Hindryckx A, De Catte L. Prenatal diagnosis ofcongenital renal and urinary tract malformations. Facts Views Vis Obgyn. 2011;3(3):165–74.
- Chavers BM, Li S, Collins AJ, Herzog CA. Cardiovascular disease in pediatric chronic dialysis patients. Kidney Int. 2002;62(2):648–53.
- Abitbol CL, Rodriguez MM. The long-term renal and cardiovascular consequences of prematurity. Nat Rev Nephrol. 2012;8(5):265–74. doi: 10.1038/nrneph.2012.38.
- Furth SL, Hwang W, Yang C, Neu AM, Fivush BA, Powe NR. Growth failure, risk of hospitalization and death for children with end-stage renal disease. Pediatr Nephrol. 2002;17(6):450–5.
- Slickers J, Duquette P, Hooper S, Gipson D.Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Pediatr Nephrol. 2007;22(4):565–72.
Supplementary files
