COMPLICATIONS AND OUTCOMES OF PREGNANCY IN CHRONIC KIDNEY DISEASE

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Abstract

Pregnancy in women with kidney disorders, even with preserved renal function, is associated with higher than in the population rates of obstetric and perinatal complications, such as eclampsia, preterm delivery, surgical deliveries and intensive care for newborns.

This article presents our own data on complications and outcomes of pregnancies in 156 women with various stages of chronic kidney disease (CKD). From these, 87 patients had CKD stage I, 29 with CKD stage II and 40 with CKD stages III, IV, V. For the first time in Russia, the authors summarize their unique experience in management of pregnancy with CKD, underline a high probability (27,5%) of its primary detection during pregnancy, discuss the algorithms of assessment, prevention and treatment of various gestational complications in CKD (pre-eclampsia, urinary tract infections, feto-placental insufficiency, anemia, acute renal damage), as well as the influence of pregnancy on renal function at long-term post-delivery. A direct correlation between the CKD stage, frequency of pre-eclampsia, feto-placental insufficiency, preterm deliveries, surgical deliveries by caesarean section and babies’ status at birth is demonstrated.

Based on their ample clinical material, they confirmprobability of favorable pregnancy outcomes in CKD patients with stable renal function without severe arterial hypertension during pregnancy: for a baby in 87%, for the mother in 90% (maintenance of the same CKD stage). The risk of persistent deterioration of renal function during pregnancy and puerperium in women with CKD is higher in CKD stage IV, as well as in the case of early development of pre-eclampsia; it also correlates with severity of the latter.

The probability of a favorable obstetric and nephrological outcome is higher when the pregnancy is planned and intensively co-managed by an obstetrician/gynaecologist and a nephrologist from early weeks of gestation onwards.

About the authors

I. G. Nikol'skaya

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: guzmoniiag@gmail.com

PhD, Scientific Secretary

Russian Federation

E. I. Prokopenko

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

MD, PhD, Professor, Chair of Transplantology, Nephrology and Artificial Organs, Postgraduate Training Faculty

Russian Federation

S. V. Novikova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Head of Observational Obstetric Department

Russian Federation

T. S. Budykina

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Head of Clinical and Diagnostic Laboratory

Russian Federation

S. N. Kokarovtseva

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

PhD, Senior Research Fellow, the Group on Molecular Genetics

Russian Federation

A. A. Yakubina

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

Junior Research Fellow, Department of Neonatology

Russian Federation

M. S. Krupskaya

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
Research Fellow Russian Federation

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Copyright (c) 2015 Nikol'skaya I.G., Prokopenko E.I., Novikova S.V., Budykina T.S., Kokarovtseva S.N., Yakubina A.A., Krupskaya M.S.

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