FACTORS OF WOMEN’S HEALTH FROM THE PERSPECTIVE OF REPRODUCTIVE AGEING AND RISK OF CARDIOVASCULAR DISORDERS

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Abstract

Prevalence of cardiovascular abnormalities in women of reproductive age is not high. However, it is during this period that the risk factors of cardiovascular disorders are being formed. They include obesity, arterial hypertension, dyslipidemia, insulin resistance, diabetes mellitus, etc. The review demonstrates the link between cardiovascular risk factors and obstetric and gynecological  isorders, starting from menarche and ending up with menopause. Degree of vascular ageing is considered to be one of indicators of age-related changes of cardiovascular system. There is an association between markers of ageing, such as length of telomers and telomerase activity, and estrogen deficiency.

About the authors

O. V. Lopatina

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

Postgraduate Student

Russian Federation

V. E. Balan

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Author for correspondence.
Email: balanmed@gmail.com

MD, PhD, Professor, Head of Research and Consultative Department

Russian Federation

O. N. Tkacheva

State Research Center for Preventive Medicine

Email: fake@neicon.ru

MD, PhD, Professor, First Deputy Director on Research and Medical Care

Russian Federation

N. V. Sharashkina

State Research Center for Preventive Medicine

Email: fake@neicon.ru

PhD, Senior Research Fellow

Russian Federation

A. S. Zhuravel'

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

Postgraduate Student

Russian Federation

References

  1. Сметник ВП, Тумилович ЛГ. Неоперативная гинекология. М.: МИА; 2006. 632 с. (Smetnik VP, Tumilovich LG. Non-surgical gynecology. Moscow: MIA; 2006. 632 p. Russian).
  2. Викторов ИВ, Сухих ГТ. Медико-биологические аспекты применения стволовых клеток. Вестник РАМН. 2002;(4):24–30. (Viktorov IV, Sukhikh GT. [Medical and biological aspects of stem cell use]. Vestnik RAMN. 2002;(4):24–30. Russian).
  3. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ; STRAW 10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Menopause. 2012;19(4):387–95.
  4. Сметник ВП, ред. Медицина климактерия. М.: Литтерра; 2006. 848 с. (Smetnik VP, editor. Medicine of climacterium. Moscow: Litterra; 2006. 848 p. Russian).
  5. Проект Федерального закона об охране репродуктивного здоровья населения Российской Федерации. Доступно на: www.opamur.ru/docs/ekspertiza/zakon_o_zdorovie.doc. (The draft of the Federal Law on Protection of Reproductive Health of the population of the Russian Federation. Available from: www.opamur.ru/docs/ekspertiza/zakon_o_zdorovie.doc. Russian).
  6. Хакер НФ, Гамбон ДК, Хобел КД. Акушерство и гинекология. Пер. с англ. М.: ГЭОТАР-Медиа; 2012. (Hacker NF, Gambone JC, Hobel CJ. Hacker and Moore’s Essentials of Obstetrics and Gynecology. Moscow: GEOTAR-Media; 2012. Russian).
  7. Дедов ИИ, Мельниченко ГА, Чеботникова ТВ, Кучма ВР, Скоблина НА, Бутрова CА, Савельева ЛВ, Андреева ЕН, Реброва ОЮ, Есаян РМ. Ожирение и половое развитие: эпидемиологическое исследование детей и подростков Московского региона. Ожирение и метаболизм. 2006;(3): 14–20. (Dedov II, Mel'nichenko GA, Chebotnikova TV, Kuchma VR, Skoblina NA, Butrova CA, Savel'eva LV, Andreeva EN, Rebrova OYu, Esayan RM. [Obesity and sexual development: an epidemiological study of children and adolescents in the Moscow region]. Ozhirenie i metabolism. 2006;(3):14–20. Russian).
  8. Дедов ИИ, Мельниченко ГА, ред. Ожирение: этиология, патогенез, клинические аспекты. М.: МИА; 2006. 465 с. (Dedov II, Mel'nichenko GA, editors. Obesity: etiology, pathophysiology, clinical aspects. Moscow: MIA; 2006. 456 p. Russian).
  9. Bates GW, Whitworth NS. Effect of body weight reduction on plasma androgens in obese, infertile women. Fertil Steril. 1982;38(4):406–9.
  10. Clark AM, Ledger W, Galletly C, Tomlinson L, Blaney F, Wang X, Norman RJ. Weight loss results in significant improvement in pregnan cy and ovulation rates in anovulatory obese women. Hum Reprod. 1995;10(10):2705–12.
  11. Conway GS, Agrawal R, Betteridge DJ, Jacobs HS. Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clin Endocrinol (Oxf ). 1992;37(2):119–25.
  12. Харченко ВП, Рожкова НИ, ред. Маммология. Национальное руководство. М.: ГЭОТАР-Медиа; 2009. 328 c. (Kharchenko VP, Rozhkova NI, editors. Mammology: national guidebook. Moscow: GEOTAR-Media; 2009. 328 p. Russian).
  13. He C, Zhang C, Hunter DJ, Hankinson SE, Buck Louis GM, Hediger ML, Hu FB. Age at menarche and risk of type 2 diabetes: results from 2 large prospective cohort studies. Am J Epidemiol. 2010;171(3):334–44.
  14. Lakshman R, Forouhi N, Luben R, Bingham S, Khaw K, Wareham N, Ong KK. Association between age at menarche and risk of diabetes in adults: results from the EPIC-Norfolk cohort study. Diabetologia. 2008;51(5):781–6.
  15. Stockl D, Doring A, Peters A, Thorand B, Heier M, Huth C, Stockl H, Rathmann W, Kowall B, Meisinger C. Age at menarche is associated with prediabetes and diabetes in women (aged 32–81 years) from the general population: the KORA F4 Study. Diabetologia. 2012;55(3):681–8.
  16. Pierce MB, Kuh D, Hardy R. The role of BMI across the life course in the relationship between age at menarche and diabetes, in
  17. a British Birth Cohort. Diabet Med. 2012;29(5): 600–3.
  18. Elks CE, Ong KK, Scott RA, van der Schouw YT, Brand JS, Wark PA, Amiano P, Balkau B, Barricarte A, Boeing H, Fonseca-Nunes A, Franks PW, Grioni S, Halkjaer J, Kaaks R, Key TJ, Khaw KT, Mattiello A, Nilsson PM, Overvad K, Palli D, Quiros JR, Rinaldi S, Rolandsson O, Romieu I, Sacerdote C, Sanchez MJ, Spijkerman AM, Tjonneland A; InterAct Consortium. Age at menarche and type 2 diabetes risk: the EPIC-InterAct study. Diabetes Care. 2013;36(11):3526–34.
  19. Dreyfus JG, Lutsey PL, Huxley R, Pankow JS, Selvin E, Fernandez-Rhodes L, Franceschini N, Demerath EW. Age at menarche and risk of type 2 diabetes among African-American and white women in the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia. 2012;55(9):2371–80.
  20. Conway BN, Shu XO, Zhang X, Xiang YB, Cai H, Li H, Yang G, Gao YT, Zheng W. Age at menarche, the leg length to sitting height ratio, and risk of diabetes in middle-aged and elderly Chinese men and women. PLoS One. 2012;7(3):e30625.
  21. Mueller NT, Odegaard AO, Gross MD, Koh WP, Yuan JM, Pereira MA. Age at menarche and cardiovascular disease mortality in Singaporean Chinese women: the Singapore Chinese Health Study. Ann Epidemiol. 2012;22(10):717–22.
  22. Qiu C, Chen H, Wen J, Zhu P, Lin F, Huang B, Wu P, Lin Q, Lin Y, Rao H, Huang H, Liang J, Li L, Gong X, Peng S, Li M, Chen L, Tang K, Chen Z, Lin L, Lu J, Bi Y, Ning G, Chen G. Associations between age at menarche and menopause with cardiovascular disease, diabetes, and osteoporosis in Chinese women. J Clin Endocrinol Metab. 2013;98(4):1612–21.
  23. Thankamony A, Ong KK, Ahmed ML, Ness AR, Holly JM, Dunger DB. Higher levels of IGF-I and adrenal androgens at age 8 years are associated with earlier age at menarche in girls. J Clin Endocrinol Metab. 2012;97(5):E786–90.
  24. Akter S, Jesmin S, Islam M, Sultana SN, Okazaki O, Hiroe M, Moroi M, Mizutani T. Association of age at menarche with metabolic syndrome and its components in rural Bangladeshi women. Nutr Metab (Lond). 2012;9(1):99.
  25. Glueck CJ, Morrison JA, Wang P, Woo JG. Early and late menarche are associated with oligomenorrhea and predict metabolic syndrome 26 years later. Metabolism. 2013;62(11): 1597–606.
  26. Stockl D, Meisinger C, Peters A, Thorand B, Huth C, Heier M, Rathmann W, Kowall B, Stockl H, Doring A. Age at menarche and its association with the metabolic syndrome and its components: results from the KORA F4 study. PLoS One. 2011;6(10):e26076.
  27. Clark AM, Ledger W, Galletly C, Tomlinson L, Blaney F, Wang X, Norman RJ. Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum Reprod. 1995;10(10):2705–12.
  28. Correa H, Jacoby J. Nutrition and fertility: some iconoclastic results. Am J Clin Nutr. 1978;31(8):1431–6.
  29. Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, Newby LK, Pina IL, Roger VL, Shaw LJ, Zhao D, Beckie TM, Bushnell C, D'Armiento J, Kris-Etherton PM, Fang J, Ganiats TG, Gomes AS, Gracia CR, Haan CK, Jackson EA, Judelson DR, Kelepouris E, Lavie CJ, Moore A, Nussmeier NA, Ofili E, Oparil S, Ouyang P, Pinn VW, Sherif K, Smith SC Jr, Sopko G, Chandra-Strobos N, Urbina EM, Vaccarino V, Wenger NK. Effectivenessbased guidelines for the prevention of cardiovascular disease in women – 2011 update: a guideline from the American Heart Association. Circulation. 2011;123(11):1243–62.
  30. Catov JM, Wu CS, Olsen J, Sutton-Tyrrell K, Li J, Nohr EA. Early or recurrent preterm birth and maternal cardiovascular disease risk. Ann Epidemiol. 2010;20(8):604–9.
  31. Lykke JA, Langhoff-Roos J, Lockwood CJ, Triche EW, Paidas MJ. Mortality of mothers from cardiovascular and nonardiovascular causes following pregnancy complications in first delivery. Paediatr Perinat Epidemiol. 2010;24(4):323–30.
  32. Wang IK, Chang SN, Liao CC, Liang CC, Chang CT, Lin HH, Liu JH, Liu YL, Chuang FR, Hsu CY, Huang CC, Sung FC. Hypertensive disorders in pregnancy and preterm delivery and subsequent stroke in Asian women: a retrospective cohort study. Stroke. 2011;42(3): 716–21.
  33. Carr DB, Utzschneider KM, Hull RL, Tong J, Wallace TM, Kodama K, Shofer JB, Heckbert SR, Boyko EJ, Fujimoto WY, Kahn SE. Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care. 2006;29(9):2078–83.
  34. Shah BR, Retnakaran R, Booth GL. Increased risk of cardiovascular disease in young women following gestational diabetes mellitus. Diabetes Care. 2008;31(8):1668–9.
  35. Oliver-Williams CT, Heydon EE, Smith GC, Wood AM. Miscarriage and future maternal cardiovascular disease: a systematic review and meta-analysis. Heart. 2013;99(22): 1636–44.
  36. Серов ВН, Кожин АА, Прилепская ВН. Клинико-физиологические основы гинекологической эндокринологии. Ростов-на-Дону: Эверест; 1988. 368 с. (Serov VN, Kozhin AA, Prilepskaya VN. Clinical and physiological basis of gynecological endocrinology. Rostov-on-Don: Everest; 1988. 368 p. Russian).
  37. Дурасова НА. Аборт и его последствия. Справочник фельдшера и акушерки. 2011;(7):20–5. (Durasova NA. [Abortion and its consequences]. Spravochnik fel'dshera i akusherki. 2011;(7):20–5. Russian).
  38. Старостина ТА, Размахнина НИ, Торганова ИГ. Планирование семьи. М.: Медицина; 1996. 78 c. (Starostina TA, Razmakhnina NI, Torganova IG. Family planning. Moscow: Meditsina; 1996.78 p. Russian).
  39. Федеральная служба государственной статистики. Официальная статистика. Население. Демография. Ожидаемая продолжительность жизни при рождении. Доступно на: http://www.gks.ru/wps/wcm/connect/rosstat_main/rosstat/ru/statistics/population/demography/# (Federal Service of State Statistics. Official statistics. Population. Demography. Life expectancy at birth. Available from: http://www.gks.ru/wps/wcm/connect/rosstat_main/rosstat/ru/statistics/population/demography/# . Russian).
  40. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics – 2012 update: a report from the American Heart Association. Circulation. 2012;125(1): e2–e220.
  41. Allsopp RC, Harley CB. Evidence for a critical telomere length in senescent human fibroblasts. Exp Cell Res. 1995;219(1):130–6.
  42. Adaikalakoteswari A, Balasubramanyam M, Ravikumar R, Deepa R, Mohan V. Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy. Atherosclerosis. 2007;195(1):83–9.
  43. Le Roith D, Taylor SI, Olefsky JM, editors. Diabetes Mellitus: A Fundamental and Clinical Text. Philadelphia: Lippincott Williams & Wilkins; 2004.
  44. Sampson MJ, Winterbone MS, Hughes JC, Dozio N, Hughes DA. Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes. Diabetes Care. 2006;29(2):283–9.
  45. Mulder H. Is shortening of telomeres the missing link between aging and the Type 2 Diabetes epidemic? Aging (Albany NY).
  46. ;2(10):634–6.
  47. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005;366(9486):6620–4.
  48. Demissie S, Levy D, Benjamin EJ, Cupples LA, Gardner JP, Herbert A, Kimura M, Larson MG, Meigs JB, Keaney JF, Aviv A. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006;5(4):325–30.
  49. Al-Attas OS, Al-Daghri N, Bamakhramah A, Shaun Sabico S, McTernan P, Huang TT. Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatr. 2010;99(6):896–9.
  50. Daubenmier J, Lin J, Blackburn E, Hecht FM, Kristeller J, Maninger N, Kuwata M, Bacchetti P, Havel PJ, Epel E. Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology. 2012;37(7): 917–28.
  51. Courtney W, Hanna CW, Bretherick KL, Gair JL, Fluker MR, Stephenson MD, Robinson WP. Telomere length and reproductive aging. Hum Reprod. 2009;24(5):1206–11.
  52. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999;340(23):1801–11.
  53. Cherif H, Tarry JL, Ozanne SE, Hales CN. Ageing and telomeres: a study into organ- and gender-specific telomere shortening. Nucleic Acids Res. 2003;31(5):1576–83.
  54. Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A. Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension. 2001;37(2 Pt 2):381–5.
  55. Jeanclos E, Schork NJ, Kyvik KO, Kimura M, Skurnick JH, Aviv A. Telomere length inverselycorrelates with pulse pressure and is highly familial. Hypertension. 2000;36(2):195–200.
  56. Aviv A. Telomeres, sex, reactive oxygen species, and human cardiovascular aging. J Mol Med (Berl). 2002;80(11):689–95.
  57. Vasa M, Breitschopf K, Zeiher AM, Dimmeler S. Nitric oxide activates telomerase and delays endothelial cell senescence. Circ Res. 2000;87(7):540–2.
  58. Lee DC, Im JA, Kim JH, Lee HR, Shim JY. Effect of long-term hormone therapy on telomere length in postmenopausal women. Yonsei Med J. 2005;46(4):471–9.
  59. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M. Estrogen activates telomerase. Cancer Res. 1999;59(23):5917–21.
  60. Rahimian R, Chan L, Goel A, Poburko D, van Breemen C. Estrogen modulation of endotheliumderived relaxing factors by human endothelial cells. Biochem Biophys Res Commun. 2004;322(2):373–9.

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Copyright (c) 2015 Lopatina O.V., Balan V.E., Tkacheva O.N., Sharashkina N.V., Zhuravel' A.S.

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