Email this article EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM
- Authors: Kulikova P.A.1, Filyushkin Y.N.2, Kulikov D.A.3, Fedulov A.V.2, Mashkov A.E.2, Kulikov A.V.4
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Affiliations:
- Lomonosov Moscow State University Moscow Regional Research and Clinical Institute (MONIKI)
- Moscow Regional Research and Clinical Institute (MONIKI)
- Moscow Regional Research and Clinical Institute (MONIKI) Institute of Theoretical and Experimental Biophysics of RAS
- Institute of Theoretical and Experimental Biophysics of RAS
- Issue: No 31 (2014)
- Pages: 21-24
- Section: ARTICLES
- URL: https://almclinmed.ru/jour/article/view/53
- DOI: https://doi.org/10.18786/2072-0505-2014-31-21-24
- ID: 53
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Abstract
Background: Development of the new methods of treatment of primary male hypogonadism is an urgent medical problem. Its solution requires a suitable experimental model of the disease. Aim: The creation of new experimental model of primary male hypogonadism. Materials and methods: The study was conducted on the male Wistar rats, hypogonadism was modeled by temporary ligation of the distal part of the spermatic cord. Results: It was shown that three-day ligation of the spermatic cord led to persistent disturbance of the testosterone-producing and reproductive functions. These manifestations were reversible at shorter duration of the exposure. Conclusion: The created model of primary male hypogonadism is characterized by the persistent testosterone-producing and reproductive functions disturbance, technical availability, non-toxicity to the other organs and systems. Availability of the model provides new opportunities for the development of approaches to treating diseases of the reproductive organs in men.
Keywords
About the authors
P. A. Kulikova
Lomonosov Moscow State UniversityMoscow Regional Research and Clinical Institute (MONIKI)
Author for correspondence.
Email: polinikul@mail.ru
laboratory worker of the Laboratory of Medical and Physics Research, MONIKI; student of the Faculty of Fundamental Medicine, MSU Russian Federation
Yu. N. Filyushkin
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
scientific worker, researcher of the Pediatric Surgery Department, MONIKI Russian Federation
D. A. Kulikov
Moscow Regional Research and Clinical Institute (MONIKI)Institute of Theoretical and Experimental Biophysics of RAS
Email: fake@neicon.ru
PhD, senior researcher of the Laboratory of Medical and Physics Research, MONIKI; researcher of the laboratory of Isotopic Investigations, ITEB of RAS Russian Federation
A. V. Fedulov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Resident Medical Practitioner of the Pediatric Surgery Department, MONIKI Russian Federation
A. E. Mashkov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
MD, PhD, Professor, Head of the Pediatric Surgery Department, MONIKI Russian Federation
A. V. Kulikov
Institute of Theoretical and Experimental Biophysics of RAS
Email: fake@neicon.ru
MD, PhD, Head of the Experimental Transplantology Department, Scientific secretary, ITEB of RAS Russian Federation
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