Genetic predictors of insulin-producing pancreatic tumor

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Abstract

Insulinoma is the most common functioning tumor of the pancreas. Approximately 5% of its cases are associated with the multiple endocrine neoplasia syndrome type 1 (MEN1), caused by mutation in the MEN1 gene. MEN1 can be manifested by pituitary and parathyroid adenomas, pancreatic neuroendocrine tumors, tumors of the thyroid gland, adrenals, intestine, carcinoids of lungs and other organs. However, in 5–10% of the patients with clinical manifestation of this syndrome, MEN1 mutations cannot be identified. Moreover, the disease can be caused by various abnormalities (mutations, polymorphisms, etc.) in other genes. More than 30 genes, associated with insulin-producing pancreatic tumors, have been described in the literature. With a known germinal mutation, the prognosis and management of patients with insulinoma can be determined by the hereditary disease with which the tumor is associated. The article emphasizes the need to search for new genetic markers that predispose to the development of insulinoma. The necessity of extended genetic testing of patients with insulinomas is discussed, primarily of young patients with multifocal lesions, family history and associated disorders.

About the authors

M. Yu. Yukina

National Medical Research Center of Endocrinology

Author for correspondence.
Email: kuronova@yandex.ru

Marina Yu. Yukina - MD, PhD, Leading Research Fellow, Department of Therapeutic Endocrinology,

11 Dmitriya Ul'yanova ul., Moscow, 117036

Russian Federation

N. F. Nuralieva

National Medical Research Center of Endocrinology

Email: fake@neicon.ru

Nurana F. Nuralieva – Research Fellow, Department of Therapeutic Endocrinology,

11 Dmitriya Ul'yanova ul., Moscow, 117036

Russian Federation

E. A. Troshina

National Medical Research Center of Endocrinology

Email: fake@neicon.ru

Ekaterina A. Troshina – MD, PhD, Professor, Member-Correspondent of Russian Academy of Sciences, Head of Department of Therapeutic Endocrinology,

11 Dmitriya Ul'yanova ul., Moscow, 117036

Russian Federation

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Copyright (c) 2019 Yukina M.Y., Nuralieva N.F., Troshina E.A.

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