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Предотвращение эпилептогенеза как будущая стратегия терапии эпилепсии

https://doi.org/10.18786/2072-0505-2019-47-028

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Аннотация

Эпилепсией страдают более 70 млн человек во всем мире. От 30 до 40% больных резистентны к  существующим лекарственным средствам. В статье описано современное состояние терапии эпилепсии и  предложен возможный подход к превентивной терапии на ранних стадиях эпилептогенеза. Для прогнозирования развития эпилепсии на ее ранних стадиях нужны биомаркеры. Единственным приемлемым биомаркером эпилептогенеза следует признать патологические высокочастотные осцилляции. Однако главное ограничение метода – необходимость имплантации электродов для их регистрации. Одной из актуальнейших тем научных исследований эпилепсии представляется поиск неинвазивных биомаркеров эпилептогенеза. В свою очередь, в этой области существуют два потенциально интересных направления: поиск воспалительных биомаркеров в  периферической крови и  анализ различных параметров, которые дают визуализирующие методы. В этой публикации мы освещаем подходы к  определению потенциальных биомаркеров эпилептогенеза с  помощью магнитно-резонансной томографии. Некоторые из параметров магнитно-резонансной томографии коррелируют с  наличием патологических высокочастотных осцилляций, могут косвенно отражать текущий воспалительный процесс в головном мозге и  стать возможными биомаркерами эпилептогенеза.

Об авторе

А. Г. Брагин
Калифорнийский университет (Лос-Анджелес)
Соединённые Штаты Америки

Брагин Анатолий Григорьевич – д-р биол. наук, науч. сотр. отделения неврологии Центра по эпилепсии
90095, Калифорния, Лос-Анджелес, Вествуд Плаза, 710



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Для цитирования:


Брагин А.Г. Предотвращение эпилептогенеза как будущая стратегия терапии эпилепсии. Альманах клинической медицины. 2019;47. https://doi.org/10.18786/2072-0505-2019-47-028

For citation:


Bragin A.G. Prevention of epileptogenesis as a future strategy for the treatment of epilepsy. Almanac of Clinical Medicine. 2019;47. https://doi.org/10.18786/2072-0505-2019-47-028

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