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Aim: To evaluate retrospectively the efficacy and safety of entecavir in treatment-naïve patients with hepatitis B viral infection.
Materials and methods: Based on patient medical documentation, we analyzed the results of clinical, virologic and instrumental assessment of 36 patients with chronic hepatitis B, 6 of whom were HBeAg-positive, and 1 had a highly active progression of acute hepatitis B. Duration of entecavir therapy (at a dose of 0,5–1 mg daily) was 48 weeks.
Results: In most patients with chronic hepatitis B, treatment with entecavir, regardless of the HBeAg status, promoted a virologic response (94.4%) and HBeAg serum conversion with anti-HBe formation (83.3%), which was associated with a clinical improvement, normalization of liver enzyme activity, reduction of liver fibrosis by 1 point (assessed by fibroelastometry). There were no changes in serum HBsAg during the antiviral therapy. A clinical case of successful entecavir therapy of hepatitis B viral infection is presented.
Conclusion: Entecavir is a highly effective and reliable agent that can suppress viral replication in various forms of acute and chronic hepatitis B viral infection. A relatively rapid recurrence of viral replication after withdrawal of the drug justifies further research to optimize treatment of chronic hepatitis B.

About the authors

L. I. Mel'nikova

The Central Medical Unit No. 165 of the Federal Biomedical Agency of Russia, Moscow

Author for correspondence.
Mel'nikova Lyubov' Ivanovna – PhD, Head of Department of Infectious Diseases Russian Federation

L. Yu. Il'chenko

Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow

Il'chenko Lyudmila Yur'evna – MD, PhD, Professor, Head of Department of Viral Hepatites Russian Federation


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Copyright (c) 2016 Mel'nikova L.I., Il'chenko L.Y.

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