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The annual rate of deep vein thrombosis in general population is from 5 to 9 cases per 10 000, whereas for venous thromboembolism (deep vein thrombosis and pulmonary embolism taken together) amounts to 14 cases per 10 000. To improve longterm results of therapy for thrombosis of deep veins of the lower extremities, it is important to restore venous function and outflow. Anticoagulant therapy with low weight or non-fractionated heparin preparations remains the most widely used method of management. However, total or partial thrombosis resolution under anticoagulant treatment is achieved only in 4 and 14% of cases, respectively. Thrombolysis allows for early resorption of the thrombus by means of a minimally invasive procedure with lower risk of complication. After the venous flow is restored, the aim of treatment is to prevent damage to the venous valves, venous hypertension and repeated thrombosis with development of the post-thrombotic syndrome. Compared to anticoagulation, systemic thrombolysis has the benefit of more rapid clot resorption and less damage to the venous valve. One of its serious limitations is a high bleeding risk related to higher doses of the drug administered through a peripheral vein catheter. Therefore, selective intra-clot administration of thombolytics (direct catheter thrombolysis) has been suggested as an alternative. For more effective therapy with the use of lower doses of thrombolytics, the so called pharmaco-mechanical thrombectomy has been developed. Venous stenosis hindering the venous outflow is frequently seen after direct catheter or pharmaco-mechanical thrombolysis. Angioplasty with stent placement is recommended in the cases with residual venous abnormality after successful thrombolysis and thrombectomy. 

About the authors

A. G. Osiev

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: osiev_ag@mail.ru

Osiev Aleksandr G. – MD, PhD, Professor, Head of Department of Cardiovascular Surgery

* 61/2–9 Shchepkina ul.,Moscow, 129110,Russian Federation. Tel.: +7 (495) 681 35 09. E-mail: osiev_ag@mail.ru 

Russian Federation

M. V. Vishnyakova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: osiev_ag@mail.ru
Vishnyakova Mariya V. – MD, PhD, Head of Department of Roentgenology Russian Federation

B. B. Gegenava

Moscow Regional Research and Clinical Institute (MONIKI)

Email: osiev_ag@mail.ru
Gegenava Boris B. – Senior Research Fellow, Department of Сardiosurgery Russian Federation


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Copyright (c) 2015 Osiev A.G., Vishnyakova M.V., Gegenava B.B.

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