Psoriasis and inflammatory bowel diseases: pathogenetic pathways and the choice of biologic therapy (a literature review)

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Abstract

Psoriasis and inflammatory bowel disease (IBD) are multifactorial chronic immuno-inflammatory potentially disabling disorders with similar genetic factors and immunological pathways, in particular, genetic polymorphisms of IL-23R, which determines the signal IL-12/23-mediated pathway of immunopathogenesis. The emergence of genetically engineered biological agents has changed the prognosis for both psoriasis and IBD. The intersection of the therapeutic spectrum in psoriasis and IBD is a very important point when choosing the management strategy for these patients. Infliximab and adalimumab are effective in the treatment of psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis (evidence level 1A). Ustekinumab demonstrates effectiveness in the treatment of psoriasis, psoriatic arthritis (evidence level 1A) and Crohn's disease (evidence level 1B). Etanercept and secukinumab have been shown to be effective against psoriasis, psoriatic arthritis (evidence level 1A) and ineffective and even associated with exacerbation risk in Crohn's disease and ulcerative colitis. Inhibition of regulatory cytokines IL-12/23 also has a number of advantages compared to the blockade of effector cytokines (TNF-α, IL-17) due to potentially long-term and stable treatment results and less frequent administration.

About the authors

L. S. Kruglova

Central State Medical Academy of the Presidential Administration of the Russian Federation

Author for correspondence.
Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265

Larisa S. Kruglova – MD, PhD, Professor, Head of the Chair of Dermatovenereology and Cosmetology

19/1A Marshala Timoshenko ul., Moscow, 121359

Russian Federation

A. N. Lvov

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Email: alvov@mail.ru
ORCID iD: 0000-0002-3875-4030

Andrey N. Lvov – MD, PhD, Professor, Head of the Department of Clinical Dermatovenereology and Cosmetology

17 Leninskiy prospekt, Moscow, 119071

Russian Federation

A. V. Kagramanova

Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department

Email: a.kagramanova@mknc.ru

Anna V. Kagramanova – MD, PhD, Senior Research Fellow, Department of Inflammatory Bowel Diseases

86 Shosse Entuziastov, Moscow, 111123

Russian Federation

O. V. Knyazev

Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department

Email: o.knyazev@mknc.ru

Oleg V. Knyazev – MD, PhD, Head of the Department of Inflammatory Bowel Diseases

86 Shosse Entuziastov, Moscow, 111123

Russian Federation

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