RARE NON-TUMOR DISEASES OF THE PHARYNX AND LARYNX

Cover Page


Cite item

Full Text

Abstract

A number of inflammatory systemic and non-systemic pharyngel and laryngeal diseases may clinically imitate a tumor. In these cases, computed tomography provides rapid assessment and significant additional information to that obtained from endoscopy. We present 4 clinical observations with certain common features. These are a suspicion of a neoplasm and absence of typical computed tomography symptoms characteristic of tumor lesions. IgG4-related systemic disease, rheumatoid arthritis, amyloidosis, and actinomycosis are rare disorders, however, they should be considered in the differential diagnosis. In this context, the knowledge of the radiation diagnostic characteristics of these rare nosologies will be useful for a practitioner.

About the authors

E. A. Stepanova

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: stepanova-moniki@mail.ru

Stepanova Elena A. – PhD, Roentgenologist, Department of X-ray Computed Tomography and Magnetic Resonance Imaging

* 61/2–9 Shchepkina ul., Moscow, 129110, Russian Federation. Tel.: +7 (495) 631 72 07. E-mail: stepanova-moniki@mail.ru

Russian Federation

M. V. Vishnyakova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

Vishnyakova Mariya V. – MD, PhD, Head of Department of Roentgenology

* 61/2–15 Shchepkina ul., Moscow, 129110, Russian Federation. Tel.: +7 (495) 684 44 33. E-mail: cherridra@list.ru

Russian Federation

D. M. Mustafaev

Moscow Regional Research and Clinical Institute (MONIKI)

Email: cherridra@list.ru
Mustafaev Dzhavanshir Mamed oglu – PhD, Senior Research Fellow, Department of Otorhinolaryngology Russian Federation

D. V. Akhtyamov

Moscow Regional Research and Clinical Institute (MONIKI)

Email: cherridra@list.ru

Akhtyamov Dmitriy V. – Research Fellow, Department of Oral and Maxillofacial Surgery

Russian Federation

L. E. Gaganov

Moscow Regional Research and Clinical Institute (MONIKI)

Email: cherridra@list.ru
Gaganov Leonid E. – MD, PhD, Chief of Department of Pathological Anatomy Russian Federation

References

  1. Deshpande V, Gupta R, Sainani N, Sahani DV, Virk R, Ferrone C, Khosroshahi A, Stone JH, Lauwers GY. Subclassification of autoimmune pancreatitis: a histologic classification with clinical significance. Am J Surg Pathol. 2011;35(1):26–35. doi: 10.1097/PAS.0b013e3182027717.
  2. Kamisawa T, Takuma K, Anjiki H, Egawa N, Kurata M, Honda G, Tsuruta K. Sclerosing cholangitis associated with autoimmune pancreatitis differs from primary sclerosing cholangitis. World J Gastroenterol. 2009;15(19):2357–60.
  3. Stone JH. IgG4-related disease: nomenclature, clinical features, and treatment. Semin Diagn Pathol. 2012;29(4):177–90. doi: 10.1053/j.semdp.2012.08.002.
  4. Plaza JA, Garrity JA, Dogan A, Ananthamurthy A, Witzig TE, Salomao DR. Orbital inflammation with IgG4-positive plasma cells: manifestation of IgG4 systemic disease. Arch Ophthalmol. 2011;129(4):421–8. doi: 10.1001/ archophthalmol.2011.16.
  5. Stone JH, Khosroshahi A, Hilgenberg A, Spooner A, Isselbacher EM, Stone JR. IgG4-related systemic disease and lymphoplasmacyticaortitis. Arthritis Rheum. 2009;60(10):3139–45. doi: 10.1002/art.24798.
  6. Wong DD, Pillai SR, Kumarasinghe MP, McGettigan B, Thin LW, Segarajasingam DS, Hollingsworth PN, Spagnolo DV. IgG4-related sclerosing disease of the small bowel presenting as necrotizing mesenteric arteritis and a solitary jejunal ulcer. Am J Surg Pathol. 2012;36(6):929–34. doi: 10.1097/PAS.0b013e3182495c96.
  7. Nishimori I, Kohsaki T, Onishi S, Shuin T, Kohsaki S, Ogawa Y, Matsumoto M, Hiroi M, Hamano H, Kawa S. IgG4-related autoimmune prostatitis: two cases with or without autoimmune pancreatitis. Intern Med. 2007;46(24):1983–9.
  8. Cheuk W, Chan AC, Lam WL, Chow SM, Crowley P, Lloydd R, Campbell I, Thorburn M, Chan JK. IgG4-related sclerosing mastitis: description of a new member of the IgG4-related sclerosing diseases. Am J Surg Pathol. 2009;33(7):1058–64. doi: 10.1097/PAS. 0b013e3181998cbe.
  9. Cheuk W, Chan JK. IgG4-related sclerosing disease: a critical appraisal of an evolving clinicopathologic entity. Adv Anat Pathol. 2010;17(5):303–32. doi: 10.1097/ PAP.0b013e3181ee63ce.
  10. Pickhard A, Smith E, Rottscholl R, Brosch S, Reiter R. Disorders of the larynx and chronic inflammatory diseases. Laryngorhinootologie. 2012;91(12):758–66. doi: 10.1055/s-00321323769.
  11. Lawry GV, Finerman ML, Hanafee WN, Mancuso AA, Fan PT, Bluestone R. Laryngeal involvement in rheumatoid arthritis. A clinical, laryngoscopic, and computerized tomographic study. Arthritis Rheum. 1984;27(8):873–82.
  12. Voulgari PV, Papazisi D, Bai M, Zagorianakou P, Assimakopoulos D, Drosos AA. Laryngeal involvement in rheumatoid arthritis. Rheumatol Int. 2005;25(5):321–5.
  13. Ylitalo R, Heimburger M, Lindestad PA. Vocal fold deposits in autoimmune disease – an unusual cause of hoarseness. Clin Otolaryngol Allied Sci. 2003;28(5):446–50.
  14. Kyle RA. Amyloidosis: a convoluted story. Br J Haematol. 2001;114(3):529–38.
  15. Sideras K, Gertz MA. Amyloidosis. Adv Clin Chem. 2009;47:1–44.
  16. Gilad R, Milillo P, Som PM. Severe diffuse systemic amyloidosis with involvement of the pharynx, larynx, and trachea: CT and MR findings. AJNR Am J Neuroradiol. 2007;28(8): 1557–8.
  17. Siddachari RC, Chaukar DA, Pramesh CS, Naresh KN, de Souza CE, Dcruz AK. Laryngeal amyloidosis. J Otolaryngol. 2005;34(1):60–3.
  18. Ergas D, Abramowitz Y, Lahav Y, Halperin D, Sthoeger ZM. Exertion dyspnea and stridor: an unusual presentation of localized laryngeal amyloidosis. Isr Med Assoc J. 2006;8(1):73–4.
  19. Morawska A, Wiatr M, Składzień J. Ways of treatment of non-malignant laryngeal tumors in older patients – laryngeal amyloidosis. Otolaryngol Pol. 2008;62(2):141–4.
  20. Belmont MJ, Behar PM, Wax MK. Atypical presentations of actinomycosis. Head Neck. 1999;21(3):264–8.
  21. Allen HA 3rd, Scatarige JC, Kim MH. Actinomycosis: CT findings in six patients. AJR Am J Roentgenol. 1987;149(6):1255–8.
  22. Silverman PM, Farmer JC, Korobkin M, Wolfe J. CT diagnosis of actinomycosis of the neck. J Comput Assist Tomogr. 1984;8(4):793–4.
  23. Nagler R, Peled M, Laufer D. Cervicofacialactinomycosis: a diagnostic challenge. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83(6):652–6.
  24. Ermis I, Topalan M, Aydin A, Erer M. Actinomycosis of the frontal and parotid regions. Ann Plast Surg. 2001;46(1):55–8.
  25. Nagler RM, Ben-Arieh Y, Laufer D. Case report of regional alveolar bone actinomycosis: a juvenile periodontitis-like lesion. J Periodontol. 2000;71(5):825–9.
  26. Weber AL, Siciliano A. CT and MR imaging evaluation of neck infections with clinical correlations. Radiol Clin North Am. 2000;38(5):941– 68, ix.
  27. Ha HK, Lee HJ, Kim H, Ro HJ, Park YH, Cha SJ, Shinn KS. Abdominal actinomycosis: CT findings in 10 patients. AJR Am J Roentgenol. 1993;161(4):791–4.
  28. Kwong JS, Muller NL, Godwin JD, Aberle D, Grymaloski MR. Thoracic actinomycosis: CT findings in eight patients. Radiology. 1992;183(1):189–92.
  29. Von Lichtenberg F. Infectious disease. In: Contran RS, Kumar V, Robbins SL, editors. Robbins pathologic basis of disease. 4th ed. Philadelphia: Saunders; 1989. p. 383–4.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2015 Stepanova E.A., Vishnyakova M.V., Mustafaev D.M., Akhtyamov D.V., Gaganov L.E.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies