Myxoid adrenal cortical carcinoma, a rare type of adrenal cortical cancer. A case report

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Abstract

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex with aggressive clinical behavior and an unfavorable prognosis. Its estimated annual incidence is 0.5 to 2 cases per 1,000 000. The unfavorable prognostic factors include its rare variants, such as myxoid ACC. This ACC type was first reported as early as in 1979; however, its low prevalence hinders any reliable assessment of its prognostic value. Few published data indicate more than 2-fold lower median survival of patients with myxoid ACC, compared to that in classical ACC. Here we present a rare clinical case of myxoid ACC in a 56-year old woman with Cushing's syndrome, invasion of the adjacent tissues and organ by the time of diagnosis, rapid progression of the disease with fatal outcome. We discuss the variations of the myxoid component, associated with different cellular growth patterns in ACC. This clinical case demonstrates the aggressive course of myxoid ACC type, compared to the classical one, and is aimed at drawing the attention of various medical specialists to rare ACC variants.

About the authors

P. A. Korosteleva

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: polina.lopatieva@gmail.com

Polina А. Korosteleva - MD, Department of Pathological Anatomy1

61/2-13 Shchepkina ul., Moscow, 129110.

Tel.: +7 (495) 631 74 22.

Russian Federation

A. V. Krivosheev

Moscow Regional Research and Clinical Institute (MONIKI)

Email: doc275@mail.ru
ORCID iD: 0000-0003-3643-6810

Alexey V. Krivosheev - MD, Junior Research Fellow, Department of Endocrine Surgery.

61/2 Shchepkina ul., Moscow, 129110.

Russian Federation

S. V. Vorontsova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: svetlanayud@yandex.ru
ORCID iD: 0000-0003-3584-4345

Svetlana V. Vorontsova - MD, PhD, Department of Diagnostic Radiology.

61/2 Shchepkina ul., Moscow, 129110.

Russian Federation

I. A. Voronkova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: iya-v@yandex.ru
ORCID iD: 0000-0001-6687-3240

Iya A. Voronkova - MD, PhD, Department of Pathological Anatomy.

61/2 Shchepkina ul., Moscow, 129110.

Russian Federation

T. A. Britvin

Moscow Regional Research and Clinical Institute (MONIKI)

Email: t.britvin@gmail.com
ORCID iD: 0000-0001-6160-1342

Timur A. Britvin - MD, PhD, Chief Research Fellow, Division of Surgery.

61/2 Shchepkina ul., Moscow, 129110.

Russian Federation

Yu. G. Krivosheeva

Moscow Regional Research and Clinical Institute (MONIKI)

Email: yulya.k.89@inbox.ru
ORCID iD: 0000-0002-2061-5235

Yulia G. Krivosheeva - MD, Department of Therapeutic Endocrinology, Division of Therapy.

61/2 Shchepkina ul., Moscow, 129110.

Russian Federation

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Copyright (c) 2020 Korosteleva P.A., Krivosheev A.V., Vorontsova S.V., Voronkova I.A., Britvin T.A., Krivosheeva Y.G.

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