PREVALENCE OF SLEEP DISORDERED BREATHING IN PATIENTS WITH NEWLY DIAGNOSED ACROMEGALY

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Abstract

Background: Obstructive sleep disordered breathing or obstructive sleep apnea (OSA) is the most common respiratory impairment in acromegaly. OSA is bound up with heightened cardiovascular mortality. Aim: Тo study frequency, features, and structure of sleep disordered breathing in patients with newly diagnosed acromegaly and to elucidate the factors influencing their development. Materials and methods: 38 patients (10 men, 28 women, median age 53 (28-76) years, median body mass index (BMI) 29 (19.9-44.3) kg/m²) with newly diagnosed acromegaly were recruited into the study. All subjects underwent full polysomnography (Embla N7000, Natus, USA) and Remlogica software (USA). Results: Sleep disordered breathing was found in 28 (73.7%) patients. OSA was revealed in all cases, in 11 (39.3%) subjects it was mixed. In 10 (35.7%) patients OSA was mild, in 8 (28.6%) moderate, and in 10 (35.7%) severe. BMI (р<0.01), disease duration (р=0.003), and insulin-like growth factor-1 (IGF-1) level (р=0.04) were different in patients without OSA and patients with moderate-to-severe OSA. No difference was found in sex (р=0.4), age (р=0.064), and growth hormone level (р=0.6). Frequency of arterial hypertension, diabetes mellitus, and other glucose metabolism impairments was the same in subjects without OSA and with severe-to-moderate OSA. Conclusion: All patients with newly diagnosed acromegaly should undergo polysomnography. BMI, disease duration, and IGF-1 level are significant risk factors for OSA development. Correlation OSA with arterial hypertension and glucose metabolism impairments needs to be further investigated.

About the authors

U. A. Tsoy

Almazov Federal Medical Research Centre (Almazov FMRC); 2 Akkuratova ul., Saint Petersburg, 197341, Russian Federation

Author for correspondence.
Email: utsoi@mail.ru
MD, PhD, leading researcher of the Institute of Endocrinology, Almazov FMRC Russian Federation

L. S. Korostovtseva

Almazov Federal Medical Research Centre (Almazov FMRC); 2 Akkuratova ul., Saint Petersburg, 197341, Russian Federation

Email: fake@neicon.ru
MD, PhD, researcher of the Laboratory of Pathogenesis and Therapy of Arterial Hypertension, Almazov FMRC Russian Federation

Yu. V. Sviryaev

Almazov Federal Medical Research Centre (Almazov FMRC); 2 Akkuratova ul., Saint Petersburg, 197341, Russian Federation

Email: fake@neicon.ru
MD, PhD, senior researcher of the Laboratory of Pathogenesis and Therapy of Arterial Hypertension, Almazov FMRC Russian Federation

A. P. Semenov

Almazov Federal Medical Research Centre (Almazov FMRC); 2 Akkuratova ul., Saint Petersburg, 197341, Russian Federation

Email: fake@neicon.ru

Physician of the Cardiologic Department No.2, junior researcher of the Laboratory of Pathogenesis and Therapy of Arterial Hypertension, Almazov FMRC

Russian Federation

D. A. Vaulina

First Pavlov State Medical University of St. Petersburg (Pavlov FSPSMU); 6-8 L’va Tolstogo ul., Saint Petersburg, 197022, Russian Federation

Email: fake@neicon.ru
physician-intern, Pavlov FSPSMU Russian Federation

S. O. Kravchenko

First Pavlov State Medical University of St. Petersburg (Pavlov FSPSMU); 6-8 L’va Tolstogo ul., Saint Petersburg, 197022, Russian Federation

Email: fake@neicon.ru

physician-intern, Pavlov FSPSMU

Russian Federation

A. O. Konradi

Almazov Federal Medical Research Centre (Almazov FMRC); 2 Akkuratova ul., Saint Petersburg, 197341, Russian Federation

Email: fake@neicon.ru

MD, PhD, Professor, Head of the Research Department of Arterial Hypertension, Deputy Director for research work, Almazov FMRC

Russian Federation

E. N. Grineva

Almazov Federal Medical Research Centre (Almazov FMRC); 2 Akkuratova ul., Saint Petersburg, 197341, Russian Federation

Email: fake@neicon.ru

MD, PhD, Professor, Director of the Institute of Endocrinology, Almazov
FMRC

Russian Federation

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Copyright (c) 2014 Tsoy U.A., Korostovtseva L.S., Sviryaev Y.V., Semenov A.P., Vaulina D.A., Kravchenko S.O., Konradi A.O., Grineva E.N.

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