Email this article Primary thyroid-like follicular renal carcinoma: a clinical case and literature review
- Authors: Volchenko N.N.1, Goeva N.S.1, Vorobyev N.V.1,2, Muradyan A.G.1,3, Ratushnaya V.V.1
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Affiliations:
- P.A. Hertsen Moscow Oncology Research Center -Branch of the National Medical Research Center of Radiology
- I.M. Sechenov First Moscow State Medical University
- Peoples' Friendship University of Russia (RUDN University)
- Issue: Vol 48, No 2 (2020)
- Pages: 140-145
- Section: CLINICAL CASES
- URL: https://almclinmed.ru/jour/article/view/1324
- DOI: https://doi.org/10.18786/2072-0505-2020-48-027
- ID: 1324
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Abstract
Primary thyroid-like follicular renal cell carcinoma is an extremely rare type of renal cell cancer with low malignancy potential and relatively good prognosis. It has not been included into the World Health Organization classification of renal tumors. This tumor is characterized by morphology similar to primary thyroid follicular cancer, but with different immune phenotype, which is important for morphological diagnosis. Surgery has been recognized as the only curative treatment. We describe our own observation of follicular renal carcinoma in a 68-year old man, in whom renal tumor was identified during his regular examination due to past colon cancer. The disease was asymptomatic. The patient had elective laparoscopic nephrectomy. At pathological assessment, the tumor looked like a follicular thyroid neoplasm. Immunohistochemistry revealed no expression of RCC, TTF-1, thyroglobulin, CD-10, synaptophysin, and chromogranin A. The differential diagnosis included metastatic primary thyroid malignancy as the most probable diagnosis, as well as highly differentiated neuroendocrine tumor and the so-called “thyroid kidney” that might occur in long-standing chronic pyelonephritis. Conclusion: The case of primary follicular renal carcinoma illustrates that this rare renal tumor is heterogeneous both in its structure and tumor cell immunophenotypes. Longer follow-up and accumulation of larger numbers of the disease is needed. This would allow for a more objective assessment of its prevalence in the population, of its clinical characteristics and morphological variability.
About the authors
N. N. Volchenko
P.A. Hertsen Moscow Oncology Research Center -Branch of the National Medical Research Center of Radiology
Email: mnioi.morphology@mail.ru
ORCID iD: 0000-0002-4873-4455
Nadezhda N. Volchenko - MD, PhD, Professor, Head of the Tumor Morphology Department.
3 2-y Botkinskiy proezd, Moscow, 125284.
Russian FederationN. S. Goeva
P.A. Hertsen Moscow Oncology Research Center -Branch of the National Medical Research Center of Radiology
Author for correspondence.
Email: natalia.lisago@yandex.ru
ORCID iD: 0000-0002-6023-2300
Natalia S. Goeva - MD, Pathologist, Tumor Morphology Department.
3 2-y Botkinskiy proezd, Moscow, 125284.
Tel.: +7 (903) 139 77 91.
Russian FederationN. V. Vorobyev
P.A. Hertsen Moscow Oncology Research Center -Branch of the National Medical Research Center of Radiology; I.M. Sechenov First Moscow State Medical University
Email: dr.vorobyev@mail.ru
ORCID iD: 0000-0003-2040-0493
Nikolay V. Vorobyev - MD, PhD, Head of the Urology Department, P.A. Hertsen Moscow Oncology Research Center -Branch of the National Medical Research Center of Radiology; Associate Professor, Chair of Oncology, Radiotherapy and Plastic Surgery, I.M. Sechenov First Moscow State Medical University.
3 2-y Botkinskiy proezd, Moscow, 125284; 8/2 Trubetskaya ul., Moscow, 119991.
Russian FederationA. G. Muradyan
P.A. Hertsen Moscow Oncology Research Center -Branch of the National Medical Research Center of Radiology; Peoples' Friendship University of Russia (RUDN University)
Email: mdmuradyan@gmail.com
ORCID iD: 0000-0002-6601-6289
Avetik G. Muradyan - MD, Urologist, Department of Urologic Oncology,P.A. Hertsen Moscow Oncology Research Center -Branch of the National Medical Research Center of Radiology; Assistant, Chair of Urology and Kidney Surgery with the Course of Urologic Oncology,Peoples' Friendship University of Russia (RUDN University).
3 2-y Botkinskiy proezd, Moscow, 125284; 6 Miklukho-Maklaya ul., Moscow, 117198.
Russian FederationV. V. Ratushnaya
P.A. Hertsen Moscow Oncology Research Center -Branch of the National Medical Research Center of Radiology
Email: vika_rat@list.ru
ORCID iD: 0000-0002-5025-3378
Viktoria V. Ratushnaya - MD, Department of Diagnostic Medical Sonography.
3 2-y Botkinskiy proezd, Moscow, 125284.
Russian FederationReferences
- Moch H, Humphrey PA, Ulbright TM, Reuter VE, editors. WHO Classification of Tumours of the Urinary System and Male Genital Organs. 4th edition. World Health Organization; 2016. 400 p.
- Eble JN, Delahunt B. Emerging entities in renal cell neoplasia: thyroid-like follicular renal cell carcinoma and multifocal oncocytoma-like tumours associated with oncocytosis. Pathology. 2018;50(1):24-36. doi: 10.1016/j.pathol.2017.09.005.
- Angell SK, Pruthi R, Freiha FS. Primary thyroidlike carcinoma of the kidney. Urology. 1996;48(4):632-5. doi: 10.1016/S0090-4295(96)00223-3.
- Amin MB, Gupta R, Ondrej H, McKenney JK, Michal M, Young AN, Paner GP, Junker K, Epstein JI. Primary thyroid-like follicular carcinoma of the kidney: report of 6 cases of a histologically distinctive adult renal epithelial neoplasm. Am J Surg Pathol. 2009;33(3):393-400. doi: 10.1097/PAS.0b013e31818cb8f5.
- Volavsek M, Strojan-Flezar M, Mikuz G. Thyroid-like follicular carcinoma of the kidney in a patient with nephrolithiasis and polycystic kidney disease: a case report. Diagn Pathol. 2013;8:108. doi: 10.1186/1746-15968-108.
- Chen X, Dou FX, Cheng XB, Guo AT, Shi HY. [Clinicopathologic characteristics of thyroid-like follicular carcinoma of the kidney: an analysis of five cases and review of literature]. Zhonghua Bing Li Xue Za Zhi. 2016;45(10): 687-91. Chinese. doi: 10.3760/cma.j.issn.0529-5807.2016.10.004.
- Chen F, Wang Y, Wu X, Zhu Y, Jiang X, Chen S, Zhang Z, Zou Z, Yang Y, Zhu K, Wang Y, Cui J, Shi BK. Clinical characteristics and pathology of thyroid-like follicular carcinoma of the kidney: Report of 3 cases and a literature review. Mol Clin Oncol. 2016;4(2):143-50. doi: 10.3892/mco.2015.682.
- Insabato L, Ben-Dor D, Galliani CA, Lastilla G, Bisceglia M. Primary thyroid and thyroid-like follicular carcinoma of the kidney versus solitary metastatic carcinoma of the thyroid: a vexing issue. Virchows Arch. 2009;454(6): 717-8. doi: 10.1007/s00428-009-0785-z.
- Ghaouti M, Roquet L, Baron M, Pfister C, Sa-bourin JC. Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature. Diagn Pathol. 2014;9:186. doi: 10.1186/s13000-014-0186-8.
- Zhang Q, Ming J, Zhang S, Qiu X. Primary micro neuroendocrine tumor arising in a horseshoe kidney with cyst: report of a case and review of literature. Diagn Pathol. 2012;7:126. doi: 10.1186/1746-1596-7-126.
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