Preservation and perfusion rehabilitation of donor organs: achievements of the last decade

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Abstract

At present, it is widely recognized that machine perfusion allows for a decreased rate of delayed function of the renal graft and of the risk of liver graft early dysfunction. The aim of the review is to present the actual changes of the donor pool related to prevailing numbers of donors by expanded criteria, to determine the prospects of expanding of the available donor pool based on their selection, as well as development of functional rehabilitation and modification at tissue, cell and molecular levels with the help of perfusion technologies. The article presents the state-of-the art view on the mechanisms of ischemic-reperfusion injury of donor organs, delineates the trends in the maintenance of their viability, and gives the literature data on the role and outlook of perfusion methods in organ transplantation. The authors provide the rationale for a comprehensive systemic approach to the assessment of the functional status of a donor organ with any baseline parameters and discuss a number of theoretical provisions on the implementation of a personalized perfusion approach to ensure the availability of transplantation care.

About the authors

O. N. Reznik

Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine; North-Western State Medical University named after I.I. Mechnikov; Academician I.P. Pavlov First St. Petersburg State Medical University

Author for correspondence.
Email: onreznik@gmail.com
ORCID iD: 0000-0003-2770-1432

Oleg N. Reznik – MD, PhD, Head of Department of Transplantology and Organ Donation; Professor, Chair of Cardiovascular Surgery, Surgery Faculty; Head of Department of Transplantology, Scientific Research Institute of Surgery and Emergency Medicine

3A Budapeshtskaya ul., Saint Petersburg, 192242, tel.: +7 (921) 935 51 91;

41 Kirochnaya ul., Saint Petersburg, 191015;

6–8 L'va Tolstogo ul., Saint Petersburg, 197022

Russian Federation

A. E. Skvortsov

Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine; North-Western State Medical University named after I.I. Mechnikov

Email: fake@neicon.ru
ORCID iD: 0000-0001-5205-0331

Andrey E. Skvortsov – MD, PhD, Surgeon, Research Fellow, Department of Transplantology and Organ Donation; Assistant, Chair of Cardiovascular Surgery, Surgery Faculty

3A Budapeshtskaya ul., Saint Petersburg, 192242;

41 Kirochnaya ul., Saint Petersburg, 191015

Russian Federation

Ya. G. Moysyuk

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
ORCID iD: 0000-0002-0002-9183

Yan G. Moysyuk – MD, PhD, Professor, Head of Department of Transplantology

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

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