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Сохранение и перфузионная реабилитация донорских органов: достижения последнего десятилетия

https://doi.org/10.18786/2072-0505-2020-48-038

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Аннотация

В настоящее время общепризнано, что аппаратная перфузия позволяет снизить частоту  отсроченной функции почечного трансплантата, риск ранней дисфункции печеночного  трансплантата. Цель обзора – представить актуальные изменения донорского пула,  связанные с превалированием доноров с расширенными критериями; определить направления максимального использования доступных донорских органов за счет их селекции, функциональной реабилитации и модификации на тканевом, клеточном и молекулярном уровне с помощью перфузионных технологий. В статье изложены современные взгляды на механизмы ишемической/реперфузионной травмы донорских органов, обозначены тенденции в решении вопросов сохранения  жизнеспособности донорских органов, приведены данные литературы о роли и перспективах перфузионных методов в трансплантации органов. Обосновывается целесообразность комплексного системного подхода к оценке функционального состояния донорского органа с любыми исходными параметрами, дается ряд теоретических положений о внедрении в практику персонифицированного перфузионного подхода для обеспечения доступности трансплантационной помощи.

Об авторах

О. Н. Резник
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И. Джанелидзе»; ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России; ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава России
Россия

д-р мед. наук, руководитель отдела трансплантологии и органного донорства; профессор кафедры сердечно-сосудистой хирургии хирургического факультета; руководитель отдела трансплантологии Научно-исследовательского института хирургии и неотложной медицины

192242, г. Санкт-Петербург, ул. Будапештская, 3А, Российская Федерация

191015, г. Санкт-Петербург, ул. Кирочная, 41, Российская Федерация

197022, г. Санкт-Петербург, ул. Льва Толстого, 6–8, Российская Федерация

Тел.: +7 (921) 935 51 91



А. Е. Скворцов
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И. Джанелидзе»; ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России
Россия

канд. мед. наук, врач-хирург, науч. сотр. отдела трансплантологии и органного донорства; ассистент кафедры сердечно-сосудистой хирургии хирургического факультета

192242, г. Санкт-Петербург, ул. Будапештская, 3А, Российская Федерация

191015, г. Санкт-Петербург, ул. Кирочная, 41, Российская Федерация



Я. Г. Мойсюк
ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»
Россия

д-р мед. наук, профессор, руководитель отдела трансплантологии

129110, г. Москва, ул. Щепкина, 61/2, Российская Федерация



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Для цитирования:


Резник О.Н., Скворцов А.Е., Мойсюк Я.Г. Сохранение и перфузионная реабилитация донорских органов: достижения последнего десятилетия. Альманах клинической медицины. 2020;48. https://doi.org/10.18786/2072-0505-2020-48-038

For citation:


Reznik O.N., Skvortsov A.E., Moysyuk Y.G. Preservation and perfusion rehabilitation of donor organs: achievements of the last decade. Almanac of Clinical Medicine. 2020;48. (In Russ.) https://doi.org/10.18786/2072-0505-2020-48-038

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