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Альманах клинической медицины

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Экспрессия контрольной точки иммунитета B7-H3 в опухоли и ее растворимой формы в сыворотке крови больных новообразованиями костей

https://doi.org/10.18786/2072-0505-2021-49-013

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Аннотация

B7-H3, также называемый CD276, представляет собой трансмембранный гликопротеин типа I, который кодируется на хромосоме 15 человека. Он был открыт еще в 2001 г. Первоначальное исследование описало его как положительный костимулятор вследствие способности стимулировать Т-клеточный ответ и продукцию IFN-Y. Однако недавние исследования показали, что B7-H3 участвует в ингибировании Т-клеток. Рецептор для B7-H3 еще не идентифицирован. Это объясняет сложную иммуномодулирующую активность B7-H3, который может иметь более одного партнера по связыванию с различными функциями. Экспрессию белка B7-H3 наблюдали на активированных иммунных клетках, таких как Т-клетки, NK-клетки и антигенпрезентирующие клетки. Интересно, что он гиперэкспресси-рован в широком спектре опухолевых клеток и связан с прогрессией заболевания и прогнозом. Особый интерес представляет также растворимая форма данного белка. Повышение содержания sB7-H3 в плазме крови больных опухолями костей может оказаться важным диагностическим критерием.

Об авторах

Н. Е. Кушлинский
Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина Минздрава России
Россия

Кушлинский Николай Евгеньевич - доктор медицинских наук, профессор, академик РАН, руководитель лаборатории клинической биохимии.

115478, Москва, Каширское шоссе, 24.

Тел.: +7 (499) 324 11 59.


Конфликт интересов:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.



О. В. Ковалева
Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина Минздрава России
Россия

Ковалева Ольга Владимировна – кандидат биологических наук, старший научный сотрудник лаборатории регуляции клеточных и вирусных онкогенов Научно-исследовательского института канцерогенеза.

115478, Москва, Каширское шоссе, 24.


Конфликт интересов:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.



А. А. Алферов
Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина Минздрава России
Россия

Алферов Александр Андреевич - врач клинической лабораторной диагностики лаборатории клинической биохимии.

115478, Москва, Каширское шоссе, 24.


Конфликт интересов:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.



Ю. Б. Кузьмин
Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина Минздрава России
Россия

Кузьмин Юрий Борисович - лаборант-исследователь лаборатории клинической биохимии.

115478, Москва, Каширское шоссе, 24.


Конфликт интересов:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.



Е. А. Сушенцов
Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина Минздрава России
Россия

Сушенцов Евгений Александрович – кандидат медицинских наук, заведующий отделением хирургических методов лечения № 14 (онкоортопедии).

115478, Москва, Каширское шоссе, 24.


Конфликт интересов:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.



И. С. Стилиди
Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина Минздрава России
Россия

Стилиди Иван Сократович – доктор медицинских наук, профессор, академик РАН, директор.

115478, Москва, Каширское шоссе, 24.


Конфликт интересов:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.



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Для цитирования:


Кушлинский Н.Е., Ковалева О.В., Алферов А.А., Кузьмин Ю.Б., Сушенцов Е.А., Стилиди И.С. Экспрессия контрольной точки иммунитета B7-H3 в опухоли и ее растворимой формы в сыворотке крови больных новообразованиями костей. Альманах клинической медицины. 2021;49(3):179-190. https://doi.org/10.18786/2072-0505-2021-49-013

For citation:


Kushlinskii N.E., Kovaleva O.V., Alferov A.A., Kuzmin Yu.B., Sushentsov E.A., Stilidi I.S. Expression of the immune checkpoint B7-H3 in tumor and its soluble form in serum of patients with bone neoplasms. Almanac of Clinical Medicine. 2021;49(3):179-190. (In Russ.) https://doi.org/10.18786/2072-0505-2021-49-013

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