DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF AUTOIMMUNE PEMPHIGUS

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Abstract

Autoimmune pemphigus is a severe, potentially fatal disease affecting skin and mucous membranes. It is characterized by the presence of IgGautoantibodies against target desmosomal antigens of stratified squamous epithelium. Despite the promising results of the molecular biological research in the area of the pathogenesis of autoimmune pemphigus during past decades, diagnosis/ differential diagnosis of pemphigus remains one of the most important problems of dermatology due to rapid progression and expansion of the skin and mucous membranes lesions and the high risk of disability and death in inadequately treated patients. Correct and timely diagnosis of autoimmune pemphigus contributes to proper treatment and reduces complications risk.

About the authors

N. V. Makhneva

Moscow Research and Practical Center of Dermatovenereology and Cosmetology; 17 Leninskiy prospekt, Moscow, 119071, Russian Federation
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.
Email: makhneva@mail.ru
MD, PhD, Professor, Deputy Director for Research1 ; Professor, Dermatovenereology and Dermato-Oncology Department, Postgraduate Medical School2 Russian Federation

E. B. Davidenko

Moscow Research and Practical Center of Dermatovenereology and Cosmetology; 17 Leninskiy prospekt, Moscow, 119071, Russian Federation

Email: fake@neicon.ru
PhD, Research Fellow, Fundamental Methods Research Laboratory Russian Federation

L. V. Beletskaya

Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs; 1 Shchukinskaya ul., Moscow, 123182, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Chief Research Fellow, Immunohistochemistry Laboratory, Clinical Pathology Department Russian Federation

References

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Copyright (c) 2016 Makhneva N.V., Davidenko E.B., Beletskaya L.V.

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