CLINICAL EFFICACY OF EXTRA-CORPOREAL PHOTOCHEMOTHERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS

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Abstract

Aim: To assess clinical efficacy of extracorporeal photochemotherapy in patients with systemic lupus erythematosus (SLE). Materials and methods: 30 SLE patients were thoroughly examined. 16 of them received medical treatment and extracorporeal photochemotherapy (treatment group), 14 patients  – routine therapy only (controls). Extracorporeal photochemotherapy involved administration of 8-methoxypsoralen 0.6 mg/kg 1.5–2 hours before the initiation of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. Cell suspension was exposed to UV-radiation (λ=320– 400 nm) using blood irradiator Julia (10–15 ml/min) during 30 minutes then re-infused. In total, 4 procedures were conducted every other day. Results: After 3 courses of extracorporeal photochemotherapy, effect (reduced eruptions) was obtained in 14 patients (46.7%). Then, the patients underwent maintenance photochemotherapy 2–3 times a year. Conclusion: Extracorporeal photochemotherapy was effective in the treatment of SLE. Immunological studies have demonstrated pathogenetic effects of extracorporeal photochemotherapy.

About the authors

A. V. Molochkov

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Deputy Director on Science, Educational Work and International Communications Russian Federation

A. V. Kil’dyushevskiy

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Leading Research Fellow, Surgical Hemocorrection and Detoxication Department Russian Federation

O. V. Karzanov

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.
Email: dr_karzanov@mail.ru
PhD, Senior Research Associate, Dermatovenereology and Dermato-Oncology Department Russian Federation

L. S. Bagapsh

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: liana-bagapsh@mail.ru
Junior Research Associate, Dermatovenereology and Dermato-Oncology Departmen Russian Federation

References

  1. Скрипкин ЮК, Бутов ЮС, ред. Клиническая дерматовенерология. Руководство для врачей. Т. 2. М.: ГЭОТАР-Медиа; 2009. 928 с. (Skripkin YuK, Butov YuS, editors. Clinical dermatovenereology. Vol. 2. Moscow: GEOTARMedia; 2009. 928 р. Russian).
  2. Молочков ВА, Кильдюшевский АВ, Мо- лочков АВ, Карзанов ОВ, Якубовская ЕС, Федулкина ВА. Клинико-иммунологические аспекты экстракорпоральной фотохимиотерапии при псориазе и псориатическом артрите. Tерапевтический архив. 2012;(10): 69–74. (Molochkov VA, Kil’dyushevskiy AV, Molochkov AV, Karzanov OV, Yakubovskaya ES, Fedulkina VA. [Clinical and immunological aspects of extracorporeal photochemotherapy for psoriasis and psoriatic arthritis]. Terapevticheskiy arkhiv. 2012;(10):69–74. Russian).
  3. Кильдюшевский АВ, Молочков ВА, Карзанов ОВ. Динамика клеточного иммунитета в процессе экстракорпоральной фотохимиотерапии у больных истинной пузырчаткой. Российский журнал кожных и венерических болезней. 2008;(4):71–6. (Kil’dyushevskiy AV, Molochkov VA, Karzanov OV. [Changes in cellular immunity during extracorporeal photochemotherapy in patients with true pemphigus]. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney. 2008;(4):71–6. Russian).
  4. Кильдюшевский АВ, Молочков ВА, Ольшанский АЯ, Молочков АВ, Фомин АМ, Гордиевская МС, Карзанов ОВ, Петренко ЕВ. Адаптивная иммунотерапия Т-клеточных лимфом кожи на основе экстракорпорального фотофереза. Российский журнал кожных и венерических болезней. 2010;(1):4–10. (Kil’dyushevskiy AV, Molochkov VA, Ol’shanskiy AYa, Molochkov AV, Fomin AM, Gordievskaya OV, Karzanov MS, Petrenko EV. [Extracorporeal photopheresis-based adaptive immunotherapy for cutaneous T-cell limphomas]. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney. 2010;(1): 4–10. Russian).
  5. Кильдюшевский АВ, Молочков ВА, Карзанов ОВ, Закария Аль-Бау. Динамика межклеточных взаимодействий у больных атопическим дерматитом в процессе экстракорпоральной фотохимиотерапии. Российский журнал кожных и венерических болезней. 2007;(6):20–6. (Kil’dyushevskiy AV, Molochkov VA, Karzanov OV, Zakariya Al’-Bau. [Changes in untercellular interactions in patients with atopic dermatitis during extracorporeal photochemotherapy]. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney. 2007;(6):20–5. Russian).
  6. Молочков ВА, Кильдюшевский АВ, Молочков АВ, ред. Фотоферез в дерматовенерологии. М.: БИНОМ; 2014. 152 с. (Molochkov VA, Kil’dyushevskiy AV, Molochkov AV, editоrs. Photopheresis in dermatovenereology. Moscow: BINOM; 2014. 152 р. Russian).
  7. Knobler RM, Graninger W, Lindmaier A, Trautinger F. Photopheresis for the treatment of lupus erythematosus. Preliminary observations. Ann N Y Acad Sci. 1991;636:340–56.
  8. Boeckler P, Liu V, Lipsker D. Extracorporeal photopheresis in recalcitrant lupus erythematosus. Clin Exp Dermatol. 2009;34(7):e295–6.
  9. Wollina U, Looks A. Extracorporeal photochemotherapy in cutaneous lupus erythematosus. J Eur Acad Dermatol Venereol. 1999;13(2): 127–30.
  10. Richard MA, Saadallah S, Lefevre P, Poullin P, Buscaylet S, Grob JJ. Extracorporeal photochemotherapy in therapy-refractory subacute lupus. Ann Dermatol Venereol. 2002;129(8– 9):1023–6.
  11. Адаскевич ВП. Диагностические индексы в дерматологии. М.: Издательство Панфило- ва / БИНОМ. Лаборатория знаний; 2014. 352 с. (Adaskevich VP. Dermatological diagnostic indexes. Moscow: Izdatel’stvo Panfilova / BINOM. Laboratoriya znaniy; 2014. 352 р. Russian).

Copyright (c) 2014 Molochkov A.V., Kil’dyushevskiy A.V., Karzanov O.V., Bagapsh L.S.

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