CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA

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Abstract

Background: To improve differential diagnosis of chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA), identification of new biological markers is needed. Aim: To differentiate between COPD and BA using modern immunological methods. Materials and methods: Surface markers of peripheral blood lymphocytes were studied in patients with COPD (n=37) and BA (n=49) exacerbation. Immunological status was also assessed in 24 healthy controls. Results: In both COPD and BA, typical inflammatory changes of T-lymphocytes, B-lymphocytes and NK-cells counts were found. Lymphocyte surface phenotype changes were significantly different in COPD and BA. In COPD, a significant elevation of blood cytotoxic T-lymphocytes (CD8+) up to 34% was demonstrated; on the contrary, in BA patients, cytotoxic T-lymphocytes (CD8+) decreased to 21%. CD16+ lymphocytes (NK-cells) were significantly increased (up to 33%) in COPD patients and corresponded to normal values in BA (~10%). Conclusion: Differences in biological markers in COPD and BA reflect distinct pathogenesis of the diseases and may be used for differential diagnosis.

About the authors

E. G. Shuganov

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.
Email: shuganov.evgeny@yandex.ru
MD, PhD, Professor, Internal Diseases Department, Postgraduate Medical School Russian Federation

N. A. Raspopina

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Internal and Occupational Diseases and Pulmonology Department Russian Federation

Zh. M. Salmasi

N.I. Pirogov Russian National Research Medical University; 1 Ostrovityanova ul., Moscow, 117997, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Department of Pathophysiology and Clinical Pathophysiology Russian Federation

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Copyright (c) 2014 Shuganov E.G., Raspopina N.A., Salmasi Z.M.

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