CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA

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Abstract

Background: To improve differential diagnosis of chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA), identification of new biological markers is needed. Aim: To differentiate between COPD and BA using modern immunological methods. Materials and methods: Surface markers of peripheral blood lymphocytes were studied in patients with COPD (n=37) and BA (n=49) exacerbation. Immunological status was also assessed in 24 healthy controls. Results: In both COPD and BA, typical inflammatory changes of T-lymphocytes, B-lymphocytes and NK-cells counts were found. Lymphocyte surface phenotype changes were significantly different in COPD and BA. In COPD, a significant elevation of blood cytotoxic T-lymphocytes (CD8+) up to 34% was demonstrated; on the contrary, in BA patients, cytotoxic T-lymphocytes (CD8+) decreased to 21%. CD16+ lymphocytes (NK-cells) were significantly increased (up to 33%) in COPD patients and corresponded to normal values in BA (~10%). Conclusion: Differences in biological markers in COPD and BA reflect distinct pathogenesis of the diseases and may be used for differential diagnosis.

About the authors

E. G. Shuganov

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.
Email: shuganov.evgeny@yandex.ru
MD, PhD, Professor, Internal Diseases Department, Postgraduate Medical School Russian Federation

N. A. Raspopina

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Internal and Occupational Diseases and Pulmonology Department Russian Federation

Zh. M. Salmasi

N.I. Pirogov Russian National Research Medical University; 1 Ostrovityanova ul., Moscow, 117997, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Department of Pathophysiology and Clinical Pathophysiology Russian Federation

References

  1. Global Initiative for Chronic Obstruction Lung Disease. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (Updated 2007). Available from: www.goldcopd.com
  2. Порядин ГВ, Салмаси ЖМ, Зильбер ИЕ. Особенности поверхностного фенотипа лимфоцитов при ХОБЛ. В: Материалы Х Международного конгресса «Современные проблемы аллергологии, иммунологии и иммунофармакологии». Казань, 20–23 мая 2009 г. с. 304. (Poryadin GV, Salmasi ZhM, Zil’ber IE. Characteristic of surface lymphocytes phenotype in COPD. In: Proceedings of the X International Congress “Contemporary issues of allergology, immunology and immunopharmacology”; 2009 May 20–23; Kazan, Russia. p. 304. Russian).
  3. Порядин ГВ, Салмаси ЖМ, Макарков АИ. Механизмы регуляции экспрессии поверхностных структур дифференцированного лимфоцита. Иммунология. 1997;(3):4–8. (Poryadin GV, Salmasi ZhM, Makarkov AI. [Surface structures expression regulatory mechanisms in differentiated lymphocyte]. Immunologiya. 1997;(3):4–8. Russian).
  4. Казимирский АН, Салмаси ЖМ, Журавлева НЕ, Семенова ЛЮ, Порядин ГВ, Алиева ЗО. Особенности иммунного ответа в процессе развития воспаления при атопии. Клиническая патофизиология. 2002;(1):5–11. (Kazimirskiy AN, Salmasi ZhM, Zhuravleva NE, Semenova LYu, Poryadin GV, Alieva ZO. [Characteristics of immune response in atopic in-flammation]. Klinicheskaya patofiziologiya. 2002;(1):5–11. Russian).
  5. Фримель Г, ред. Иммунологические методы. [Перевод с нем.]. М.: Медицина; 1987. 472 с. (Friemel H, editor. Immunological working methods. Moscow: Meditsina; 1987. 472 p. Russian).
  6. Harnett M, Rigley K. The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation. Immunol Today. 1992;13(12):482–6.
  7. Stalder T, Hahn S, Erb P. Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity. J Immunol. 1994;152(3):1127–33.
  8. Robertson MJ, Cameron C, Lazo S, Cochran KJ, Voss SD, Ritz J. Costimulation of human natural killer cell proliferation: role of accessory cytokines and cell contact-dependent signals. Nat Immun. 1996–1997;15(5):213–26.
  9. Schwarting R, Castello R, Moldenhauer G, Pezzutto A, von Hoegen I, Ludwig WD, Parnes JR, Dörken B. Human Lyb-2 homolog CD72 is a marker for progenitor B-cell leukemias. Am J Hematol. 1992;41(3):151–8.
  10. Howard LM, Reen DJ. CD72 ligation regulates defective naive newborn B cell responses. Cell Immunol. 1997;175(2):179–88.

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Copyright (c) 2014 Shuganov E.G., Raspopina N.A., Salmasi Z.M.

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