ERUPTIVE KERATOACANTHOMA OF GRZYBOWSKI

Cover Page


Cite item

Abstract

The article presents a case of a very rare disorder – generalized eruptive keratoacanthoma of Grzybowski in a woman aged 82 years old. The disease is characterized by sudden emergence of hundreds or thousands of neoplasms (2–5 cm in diameters) rapidly spreading throughout the body skin. It is frequently associated with internistic cancer. In this case, generalized eruptive keratoacanthoma of Grzybowski was diagnosed 4 years after the disease onset. The authors emphasize the role of proper diagnosis and treatment of this pathology. Aromatic retinoids were highly effective in the therapy of generalized eruptive keratoacanthoma of Grzybowski.

About the authors

V. A. Molochkov

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Head of the Dermatovenereology and Dermato-Oncology Department Russian Federation

Zh. S. Kuntsevich

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.
Email: j_s_k@mail.ru
MD, PhD, Associate Professor, Dermatovenereology and Dermato-Oncology Department Russian Federation

M. A. Bobrov

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: fake@neicon.ru
Research Associate, Department of Pathological Anatomy Russian Federation

S. A. Dibirova

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: fake@neicon.ru

Fellow, Department of Skin and Venereal Diseases, Institute for Professional Education 

 

Russian Federation

References

  1. Nofal A, Assaf M, Nofal E, Alradi M. Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation. J Eur Acad Dermatol Venereol. 2014;28(4):397–404.
  2. Winkelmann RK, Brown J. Generalized eruptive keratoacanthoma. Report of cases. Arch Dermatol. 1968;97(6):615–23.
  3. Rath S, Cowan BJ, Dolman PJ. Cicatricial ectro-pion in grzybowski type of multiple eruptive keratoacanthomas. Ophthal Plast Reconstr Surg. 2014;30(2):e42–3.
  4. Lloyd KM, Madsen DK, Lin PY. Grzybowski’s eruptive keratoacanthoma. J Am Acad Dermatol. 1989;21(5 Pt 1):1023–4.
  5. Schwartz RA. The keratoacanthoma: a review. J Surg Oncol. 1979;12:315–17.
  6. Sterry W, Steigleder GK, Pullmann H, Bauermeister K. Eruptive keratoacanthoma. Hautarzt. 1981;32(3):119–25.
  7. Muir EG, Bell AJ, Barlow KA. Multiple primary carcinomata of the colon, duodenum, and larynx associated with kerato-acanthomata of the face. Br J Surg. 1967;54(3):191–5.
  8. Chapman RS, Finn OA. Carcinoma of the larynx in two patients with keratoacanthoma. Br J Dermatol. 1974;90(6):685–8.
  9. Kavanagh GM, Marshman G, Hanna MM. A case of Grzybowski’s generalized eruptive keratoacanthomas. Australas J Dermatol. 1995;36(2):83–5.
  10. Jaber PW, Cooper PH, Greer KE. Generalized eruptive keratoacanthoma of Grzybowski. J Am Acad Dermatol. 1993;29(2 Pt 2):299–304.
  11. Blitstein-Willinger E, Haas N, Nürnberger F, Stüttgen G. Immunological findings during treatment of multiple keratoacanthoma with etretinate. Br J Dermatol. 1986;114(1): 109–16.
  12. Consigli JE, González ME, Morsino R, Guidi A, Chappuis JM, Papa M, Maldonado S. Genera-lized eruptive keratoacanthoma (Grzybowski variant). Br J Dermatol. 2000;142(4):800–3.
  13. Grine RC, Hendrix JD, Greer KE. Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. J Am Acad Dermatol. 1997;36(5 Pt 1):786–7.
  14. Anzalone CL, Cohen PR. Generalized eruptive keratoacanthomas of Grzybowski. Int J Dermatol. 2014;53(2):131–6.
  15. Oakley A, Ng S. Grzybowski’s generalized eruptive keratoacanthoma: remission with cyclophosphamide. Australas J Dermatol. 2005;46(2):118–23.
  16. Молочков ВА, Казанцева ИА, Кунцевич ЖС, Бочкарева ЕВ. Кератоакантома. Дифференциальная диагностика с плоскоклеточным раком кожи. М.: БИНОМ; 2006. 224 с. (Molochkov VA, Kazantseva IA, Kuntsevich ZhS, Bochkareva EV. Keratoacanthoma. Differential diagnosis with squamous cell carcinoma of the skin. Moscow: BINOM; 2006. 224 p. Russian).
  17. Молочков ВА, Молочков АВ, Хлебникова АН, Кунцевич ЖС. Эпителиальные опухоли кожи. М.: БИНОМ; 2012. 224 с. (Molochkov VA, Molochkov AV, Khlebnikova AN, Kuntsevich ZhS. Epithelial skin tumors. Moscow: BINOM; 2012. 224 р. Russian).

Copyright (c) 2014 Molochkov V.A., Kuntsevich Z.S., Bobrov M.A., Dibirova S.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies