NICOTINAMIDE IN COMPLEX TREATMENT OF LARGE-PLAQUE PARAPSORIASIS AND EARLY STAGES OF MALIGNANT T-CELL SKIN LYMPHOMAS

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Abstract

Aim: To assess clinical efficacy of nicotinamide in 2 the treatment of patients with early stages of malignant T-cell skin lymphomas and large-plaque parapsoriasis. Materials and methods: 12 patients with erythematous stage of mycosis fungoides and 14 patients with large-plaque parapsoriasis were treated by nicotinamide 15 mg twice daily during 2 weeks. Treatment cycles were repeated 4–5 times per year; topical therapy was also administrated. Results: Nicotinamide demonstrated high therapeutic effect and good tolerability in patients with early stage of mycosis fungoides and large-plaque parapsoriasis. Stable remission was achieved in 1  woman with malignant T-cell lymphoma and 12  patients with large-plaque parapsoriasis; significant clinical improvement was shown in 8 and 12 patients, respectively. Conclusion: Thus, nicotinamide is recommended for comprehensive treatment of large-plaque parapsoriasis and early stages of mycosis fungoides.

About the authors

I. V. Khamaganova

N.I. Pirogov Russian National Research Medical University; 1 Ostrovityanova ul., Moscow, 117997, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Dermatovenereology and Cosmetology Department, Postgraduate Medical School Russian Federation

O. N. Pomerantsev

Moscow Research and Practical Center of Dermatovenereology and Cosmetology; 17
Leninskiy prospect, Moscow, 119071, Russian Federation
Peoples’ Friendship University of Russia; 6 Mikluho-Maklaya ul., Moscow, 117198, Russian
Federation

Email: fake@neicon.ru

MD, PhD, the Head of Veshnyakovsky Branch;

Associate Professor, Clinical Mycology and Dermatovenereology Department

Russian Federation

O. L. Novozhilova

Moscow Research and Practical Center of Dermatovenereology and Cosmetology; 17
Leninskiy prospect, Moscow, 119071, Russian Federation

Email: fake@neicon.ru
the Chief of the Department of Specialized Care, Veshnyakovsky Branch Russian Federation

V. P. Mitroshina

Moscow Research and Practical Center of Dermatovenereology and Cosmetology; 17
Leninskiy prospect, Moscow, 119071, Russian Federation

Author for correspondence.
Email: viktoriya_mitroshina@mail.ru
Dermatologist, Shchelkovsky Branch Russian Federation

O. I. Shvets

Moscow Research and Practical Center of Dermatovenereology and Cosmetology; 17
Leninskiy prospect, Moscow, 119071, Russian Federation

Email: fake@neicon.ru
Dermatologist, Central Branch Russian Federation

References

  1. Потекаев НС, Виноградова ЮЕ, Потекаев СН. Грибовидный микоз. В: Скрипкин ЮК, Бутов ЮС, Иванов ОЛ, ред. Дерматовенерология. Национальное руководство. М.: ГЭОТАР-Медиа; 2011. c. 955–65. (Potekaev NS, Vinogradova YuE, Potekaev SN. Mycosis fungoides. In: Skripkin YuK, Butov YuS, Ivanov OL, editors. Dermatovenereology. National guidelines. Moscow: GEOTAR-Media; 2011. p. 955–65. Russian).
  2. Молочков ВА, Кильдюшевский АВ, Ермилова АИ. Экстракорпоральная фотохимиотерапия в лечении Т-клеточных злокачественных лимфом кожи. Российский журнал кожных и венерических болезней. 2005;(4):33–8.
  3. (Molochkov VA, Kil’dyushevskiy AV, Ermilova AI. [Extracorporeal photochemotherapy in the treatment of malignant cutaneous T-cell lymphomas]. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney. 2005;(4):33–8. Russian).
  4. Молочков АВ, Ковригина АМ, Кильдюшевский АВ, Караулов АВ. Лимфома кожи. М.: БИНОМ; 2012. 184 с. (Molochkov AV, Kovrigina AM, Kil’dyushevskiy AV, Karaulov AV. Cutaneous lymphomas. Moscow: BINOM; 2012. 184 р. Russian).
  5. Разнатовский КИ, Родионов АН, Скрек СВ. Организация оказания медицинской помощи больным первичными лимфомами кожи на современном этапе. Клиническая дерматология и венерология. 2012;(1):4–8. (Raznatovskiy KI, Rodionov AN, Skrek SV. [Organization of health care delivery to the patients presenting with primary cutaneous lymphoma in the modern period]. Kliniches kaya dermatologiya i venerologiya. 2012;(1):4–8. Russian).
  6. Kaplan JB, Guitart J, Giles FJ. Targeted therapies for cutaneous T-cell lymphomas. Expert Rev Hematol. 2014;7(4):481–93.
  7. Damian D, Thomson B, Kim B, Halliday G. Nicotinamide for skin cancer chemoprevention: enhancement of DNA repair after ultraviolet and arsenic exposure by replenishing cellular energy. Brit J Dermatol. 2014;171 Suppl 4: 1–76.
  8. Damian D, Kim B, Thomson B, Halliday G. Nicotinamide replenishes cellular energy and enhances DNA repair in UV-irradiated human melanocytes and keratinocytes. J Invest Dermatol. 2014;134 Suppl 2:S83.

Copyright (c) 2014 Khamaganova I.V., Pomerantsev O.N., Novozhilova O.L., Mitroshina V.P., Shvets O.I.

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