EXTRA-CORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF LYMPHOMATOID PAPULOSIS AND FOLLICULOTROPIC MYCOSIS FUNGOIDES: CASE REPORTS

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Abstract

Aim: To assess clinical efficacy of extra-corporeal photochemotherapy (EPCT) in the treatment of rare lymphomas  – lymphomatoid papulosis and folliculotropic mycosis fungoides. Materials and methods: This is a presentation of two cases of lymphomatoid papulosis and folliculotropic mycosis fungoides treated with EPCT with duration of follow-up 9 and 12  years. Extracorporeal photochemotherapy involved administration of 8-methoxypsoralen 0.6 mg/kg 1.5–2 hours before the initiation of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. Cell suspension was exposed to UVA-radiation (λ=320–400  nm) using blood irradiator Julia (10–15 ml/min) during 30 minutes then re-infused. In total, 4 procedures were conducted every other day. Results: Both patients demonstrated positive effect involving regression of the rashes after 3 EPCT cycles. Subsequently, the patients received maintenance EPCT 2–3 times a year. Conclusion: High clinical efficacy of EPCT was demonstrated in 2  patients with lymphomatoid papulosis and folliculotropic mycosis fungoides after 9 and 12 years of follow-up.

About the authors

A. V. Kil’dyushevskiy

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: fake@neicon.ru
MD, PhD, Professor, Leading Research Associate, Surgical Hemocorrection and Detoxication Department Russian Federation

O. V. Karzanov

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.
Email: dr_karzanov@mail.ru
PhD, Senior Research Associate, Dermatovenereology and Dermato-Oncology Department Russian Federation

N. M. Aleksandrovа

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: fake@neicon.ru
MD, PhD, Associate Professor, Dermatovenereology and Dermato-Oncology Department Russian Federation

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Copyright (c) 2014 Kil’dyushevskiy A.V., Karzanov O.V., Aleksandrovа N.M.

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