TRANSIMMUNIZATION IN THE TREATMENT OF MULTIPLE SCLEROSIS

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Abstract

Aim: To study efficacy of the trans-immunization method in remitting-relapsing multiple sclerosis.

Materials and methods: The study included 15 adult patients with remitting multiple sclerosis, in 14 of whom transimmunization was used; 1 female patient during the relapse was administered photopheresis without transimmunization (without mononuclear incubation). Clinical assessment of treatment efficacy was performed with Kurtzke Expended Disability Scale (EDSS). Also, subpopulations of peripheral blood lymphocytes and levels of IgA, IgM, IgG, TNF-α were measured.

Results: After 6 courses of transimmunization, the disease process was improved or stabilized in 70% of patients, whereas 30% of patients progressed further. After transimmunization, CD5+ counts significantly increased from 76.6 ± 4.1 to 86.0 ± 2.3% (p < 0.05), HLA-DR+ decreased from 15.3 ± 6.5 to 8.5 ± 1.69% (р < 0.05), the levels of IgG, IgМ and TNF-α in peripheral blood also decreased (p > 0.05). No treatment-related adverse effects were registered.

Conclusion: The data obtained shows efficacy and safety of the transimmunization method in the treatment of multiple sclerosis. It is necessary to continue studies in larger patient numbers, as well as with longer follow-up.

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About the authors

A. V. Kil'dyushevskiy

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: fake@neicon.ru

MD, PhD, Professor, Leading Research Fellow, Surgical Hemocorrection and Detoxication Department1

Russian Federation

A. V. Borodin

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

Physician, Department of Neurology

Russian Federation

A. V. Molochkov

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Professor, Deputy Director on Science, Educational Work and International Communications1

Russian Federation

O. P. Sidorova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: sidorovaop2008@rambler.ru

MD, PhD, Leading Research Fellow, Department of Neurology; Professor, Chair of Neurology, Postgraduate Training Faculty

Russian Federation

S. V. Kotov

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Professor; Head of Department of Neurology; Head of Chair of Neurology, Postgraduate Training Faculty

Russian Federation

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Copyright (c) 2015 Kil'dyushevskiy A.V., Borodin A.V., Molochkov A.V., Sidorova O.P., Kotov S.V.

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