IMMUNOLOGICAL ASPECTS OF ENDOMETRIAL DISEASE

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Abstract

Background: Immunological processes involving peritoneal macrophages could play a critical role in pathophysiology of external genital endometriosis.

Aim: To assess levels of MCP-1, RANTES, and C-reactive protein and to identify their correlations with endometriosis.

Materials and methods: Seventy two patients were evaluated: 26 healthy controls and 46 with endometriosis. Patients were divided into groups as follows: 17 with superficial endometriosis, 18 with endometriomas and 11 with deep infiltrative endometriosis. All patients underwent a laparoscopy during the proliferative phase of the cycle; levels of peritoneal and serum MCP-1, RANTES and C-reactive protein were measured using standard ELISA assays.

Results: There were positive correlations between serum MCP-1 (p = 0.03) and C-reactive protein(p = 0.045) and severity of endometriosis, that could indicate malfunctioning of peritoneal macrophages in advanced stages of endometriosis. Conclusion: MCP-1 and C-reactive protein levels in peripheral blood can be used as markers of endometriosis activity.

About the authors

B. A. Slobodyanyuk

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

PhD, Research Fellow, Endoscopic Surgery Department

Russian Federation

A. A. Popov

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

MD, PhD, Professor, Head of Endoscopic Surgery Department

Russian Federation

T. Z. Chanturia

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Author for correspondence.
Email: dr-teona@mail.ru

Postgraduate Student

Russian Federation

T. N. Manannikova

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

PhD, Senior Research Fellow, Endoscopic Surgery Department

Russian Federation

O. V. Machanskite

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

PhD, Research Fellow, Endoscopic Surgery Department

Russian Federation

A. A. Fedorov

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

PhD, Research Fellow, Endoscopic Surgery Department

Russian Federation

T. S. Budykina

Moscow Regional Scientific Research Institute for Obstetrics and Gynecology

Email: fake@neicon.ru

MD, PhD, Head of Clinical Diagnostic Laboratory

Russian Federation

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Copyright (c) 2015 Slobodyanyuk B.A., Popov A.A., Chanturia T.Z., Manannikova T.N., Machanskite O.V., Fedorov A.A., Budykina T.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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