PULMONARY EMBOLISM: ISSUES OF CLINICAL MANIFESTATION, DIAGNOSTICS AND THERAPY

Cover Page


Cite item

Abstract

In this lecture the author highlights various aspects of pulmonary thromboembolism (PTE) with evidence-based data and his own observations for many years. Risk factors for PTE and deep vein thrombosis of lower extremities are described in details, as well as clinical manifestations of PTE depending on localization of an embolus in pulmonary arterial tree. Current diagnostic approached to PTE are presented, including perfusion scintigraphy, pulmonary angiography, ileocavagraphy, measurement of D-dimer levels. Methods of surgical and medical treatment, including their indications, are described.

About the authors

M. A. Gurevich

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: magurevich@mail.ru

MD, PhD, Professor, Department of Internal Diseases, Postgraduate Medical Faculty

Russian Federation

References

  1. Яковлев ВБ. Тромбоэмболия легочной артерии. Диагностика, лечение, профилактика. Русский медицинский журнал. 1998;(1):1036–47. Yakovlev VB. Tromboemboliya legochnoy arterii. Diagnostika, lechenie, profilaktika [Pulmonary thromboembolism. Diagnostics, treatment, prevention]. Russkiy meditsinskiy zhurnal [Russian Medical Journal]. 1998;(1):1036–47 (in Russian).
  2. Гриффин Б, Тополь Э, ред. Кардиология. Пер. с англ. М.: Практика; 2008. 1248 с. Griffin B, Topol E, editors. Kardiologiya [Handbook of Cardiology]. Transl. from Engl. Moscow: Praktika; 2008. 1248 p. (in Russian).
  3. Воробьева НМ, Панченко ЕП, Добровольский АБ, Титаева ЕВ, Ермолина ОВ, Балахонова ТВ, Хасанова ЗБ, Постнов АЮ, Кириенко АИ. Факторы, ассоциирующиеся с повышением Д-димера у больных венозными тромбоэмболическими осложнениями. Российский кардиологический журнал. 2012;(4):18–24. Vorob'eva NM, Panchenko EP, Dobrovol'skiy AB, Titaeva EV, Ermolina OV, Balakhonova TV, Khasanova ZB, Postnov AYu, Kirienko AI. Faktory, assotsiiruyushchiesya s ovysheniem D-dimera u bol'nykh venoznymi tromboembolicheskimi oslozhneniyami [Factors associated with increased levels of D-dimer in patients with venous thromboembolic complications]. Rossiyskiy kardiologicheskiy zhurnal [Russian Journal of Cardiology]. 2012;(4):18–24 (in Russian).
  4. Jug B, Vene N, Salobir BG, Sebestjen M, Sabovic M, Keber I. Prognostic impact of haemostatic derangements in chronic heart failure. Thromb Haemost. 2009;102(2):314–20.
  5. Tita-Nwa F, Bos A, Adjei A, Ershler WB, Longo DL, Ferrucci L. Correlates of D-dimer in older persons. Aging Clin Exp Res. 2010;22(1):20–3.
  6. Olschewski H, Hoeper MM, Behr J, Ewert R, Meyer A, Borst MM, Winkler J, Pfeifer M, Wilkens H, Ghofrani HA, Nikkho S, Seeger W. Long-term therapy with inhaled iloprost in patients with pulmonary hypertension. Respir Med. 2010;104(5):731–40.
  7. Ghofrani HA, Galie N, Grimminger F, Grunig E, Humbert M, Jing ZC, Keogh AM, Langleben D, Kilama MO, Fritsch A, Neuser D, Rubin LJ; PATENT-1 Study Group. Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med. 2013;369(4):330–40.
  8. Ghofrani HA, D'Armini AM, Grimminger F, Hoeper MM, Jansa P, Kim NH, Mayer E, Simonneau G, Wilkins MR, Fritsch A, Neuser D, Weimann G, Wang C; CHEST-1 Study Group. Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. N Engl J Med. 2013;369(4):319–29.

Copyright (c) 2015 Gurevich M.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies