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Альманах клинической медицины

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ФИЗИОЛОГИЧЕСКАЯ РОЛЬ ФАКТОРОВ РОСТА И КОСТНЫХ МОРФОГЕНЕТИЧЕСКИХ ПРОТЕИНОВ В ОСТЕОГЕНЕЗЕ И ЗАЖИВЛЕНИИ ПЕРЕЛОМОВ КОСТИ

https://doi.org/10.18786/2072-0505-2015-38-113-126

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Аннотация

Заживление переломов трубчатых костей остается главной проблемой современной ортопедии. Регенерация костной ткани и срастание перелома представляет собой сложный физиологический процесс, который регулируется множеством биологически активных молекул. Многочисленные факторы модифицируют каскад молекулярных событий, влияющий на разные стадии созревания остеобластов и хондробластов на таких этапах, как миграция, пролиферация, хемотаксис, дифференцировка, ингибирование и синтез внеклеточных белков. В недавно опубликованном обзоре рассмотрены механизмы, при помощи которых факторы роста и дифференцировки регулируют процесс срастания костного перелома. Благодаря достижениям в клеточной и молекулярной биологии костной ткани обнаружено большое число сигнальных молекул, участвующих в формировании тканей скелета, включая большое семейство ростовых факторов (трансформирующего фактора роста β, протеинов костного морфогенеза, фактора роста фибробластов, сосудистого эндотелиального ростового фактора, инсулиноподобного фактора роста, тромбоцитарного фактора роста), а также цитокинов и интерлейкинов. Накапливается все больше доказательств того, что они являются важнейшими регуляторами процессов пролиферации и дифференцировки клеток, биосинтеза внеклеточного вещества и минерализации костной ткани. Четкое понимание клеточных и молекулярных механизмов репарации переломов очень важно не только для разработки современных методов лечения переломов, но и для углубления понимания механизмов роста и регенерации скелета, а также механизмов старения. Это позволяет предполагать, что в будущем эти знания могут сыграть одну из основных ролей в разработке методов лечения костной патологии и стимуляции срастания переломов.

Об авторе

C. Сагаловски
Клиника Медиан
Россия

д-р мед. наук, отделение ортопедии



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Для цитирования:


Сагаловски C. ФИЗИОЛОГИЧЕСКАЯ РОЛЬ ФАКТОРОВ РОСТА И КОСТНЫХ МОРФОГЕНЕТИЧЕСКИХ ПРОТЕИНОВ В ОСТЕОГЕНЕЗЕ И ЗАЖИВЛЕНИИ ПЕРЕЛОМОВ КОСТИ. Альманах клинической медицины. 2015;(38):113-126. https://doi.org/10.18786/2072-0505-2015-38-113-126

For citation:


Sagalovsky S. Physiological role of growth factors and bone morphogenetic proteins in osteogenesis and bone fracture healing: а review. Almanac of Clinical Medicine. 2015;(38):113-126. (In Russ.) https://doi.org/10.18786/2072-0505-2015-38-113-126

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ISSN 2072-0505 (Print)
ISSN 2587-9294 (Online)