ASSESSMENT OF THE RESIDUAL TUMOR IN PATIENTS WITH MULTIPLE MYELOMA BASED ON THE ANALYSIS OF THE FREE LIGHT CHAINS OF IMMUNOGLOBULINS IN BLOOD SERUM

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Abstract

Efficiency of the multiple myeloma treatment with chemotherapy including bortezomib was assessed based on determination of the level of immunoglobulin free light chains in blood serum. The method enables estimation of changes in kinetic parameters of the residual tumor, detection of the disease course prognosis, and the choice of the optimal approach to the disease therapy.

About the authors

T. A. Мitina

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Author for correspondence.
Email: fake@neicon.ru
Russian Federation

A. K. Golenkov

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

A. Yu. Baryshnikov

Russian Oncologic Research Center n.a. N.N. Blokhin, RAMS RF, Moscow

Email: fake@neicon.ru
Russian Federation

A. V. Karaulov

First Moscow State Medical University n.a. I.M. Sechenov

Email: fake@neicon.ru
Russian Federation

E. V. Trifonova

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

Yu. B. Chernykh

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

E. V. Katayeva

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

T. D. Lutskaya

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

L. L. Vysotskaya

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

G. A. Dudina

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

S. G. Zacharov

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

A. M. Fomin

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

N. V. Lyubimova

Russian Oncologic Research Center n.a. N.N. Blokhin, RAMS RF, Moscow

Email: fake@neicon.ru
Russian Federation

I. N. Kogarko

Research Institute of Chemical Physics n.a. N.N. Semionov, RAS, Moscow

Email: fake@neicon.ru
Russian Federation

References

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  2. Голенков А.К., Митина Т.А., Когарко И.Н. и др. Фармакодинамическая характеристика эффективности велкейда при резистентной и рецидивной множественной миеломе на основе анализа свободных легких цепей иммуноглобулинов сыворотки крови // Тер. арх. 2009. №7. С.37-41.
  3. Голенков А.К., Митина Т.А., Луцкая Т.Д. и др. Клиническое значение анализа свободных легких цепей иммуноглобулинов сыворотки при множественной миеломе с различным ответом на химиотерапию // Рос. биотерапевт. журн. 2007. №3. С.71-75.
  4. Митина Т.А., Голенков А.К., Луцкая Т.Д. и др. Эффективность лечения больных множественной миеломой, осложненной почечной недостаточностью, бортезомибсодержащими программами в сочетании с гемодиализом // Гематол. трансфузиол. 2011. №4. С.12-16.
  5. Bradwell A.R., Carr-Smith H.D., Mead T.P. et al. Serum test for assessment of patients with Bence-Jones myeloma // Lancet. 2003. V.361. P.489-491.
  6. Bradwell A.R., Evans N.D., Chappell M.J. et al. Rapid removal of free light chain from serum by hemodialysis for patients with myeloma kindney // Blood. 2005. V.106, No.11. P.3482.
  7. Durie B.G.M. The importance of the new international uniform response criteria for multiple myeloma // Am. J. He-matol. Oncol. 2007. V.6, No.5. P.15-18.
  8. Katzmann J.A., Clarke R.J., Abraham R.S. et al. Serum Reference intervals and diagnostic ranges for free κ and free λ immunoglobulin light. Relative sensitivity for detection of monoclonal light chains // Clin. Chem. 2002. V.48. P.1437-1444.
  9. Mead T.P., Carr-Smith H.D., Drayson M.T. et al. Strum free light chains for monitoring multiple myeloma // Brit. J. Haematol. 2004. V.126. P.348-354.

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Copyright (c) 2013 Мitina T.A., Golenkov A.K., Baryshnikov A.Y., Karaulov A.V., Trifonova E.V., Chernykh Y.B., Katayeva E.V., Lutskaya T.D., Vysotskaya L.L., Dudina G.A., Zacharov S.G., Fomin A.M., Lyubimova N.V., Kogarko I.N.

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