THE USE OF CONFOCAL LASER SCANNING MICROSCOPY IN THE DIAGNOSTICS OF BULLOUS PEMPHIGOID OF LEVER

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Abstract

Diagnostics of autoimmune bullous dermatoses, including bullous pemphigoid of Lever that is characterized by a large variety of clinical manifestations and in many cases by severe course and high mortality, remains one of the most complicated problems in dermatology. High diagnostic error rates are to be explained not only by variability of the forms of bullous pemphigoid of Lever, but also by insufficient accuracy of existing diagnostic methods, as well as by the complexity of their implementation. Non-invasive diagnostic methods have an undoubted advantage because they allow for prompt results of the assessment and therefore to fasten the initiation of therapy and to avoid damage to the skin, which is extremely important for patients with an autoimmune bullous dermatosis. The most accurate among non-invasive methods is a confocal laser scanning microscopy. The article describes the main features of the method and its potential application for the diagnosis of bullous pemphigoid of Lever with two clinical cases.

About the authors

O. Yu. Olisova

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Author for correspondence.
Email: erika-mma@yandex.ru

MD, PhD, Professor, Head of the Chair of Skin and Venereal Diseases

Russian Federation

N. P. Teplyuk

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: erika-mma@yandex.ru
MD, PhD, Professor, Chair of Skin and Venereal Diseases Russian Federation

S. B. Tkachenko

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: erika-mma@yandex.ru

MD, PhD, Professor, Member-Correspondent of Russian Academy of Sciences, Research Department of Immunodependent Dermatoses, Research Center

Russian Federation

V. A. Varshavskiy

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: erika-mma@yandex.ru
MD, PhD, Professor, Chair of Pathological Anatomy Russian Federation

V. A. Zaydenov

Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs; 1 Shchukinskaya ul., Moscow, 123182, Russian Federation

Email: erika-mma@yandex.ru
MD, PhD, Senior Research Fellow, Laboratory of Department of Clinical Pathology and Immunohistochemistry Russian Federation

A. S. Allenova

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: erika-mma@yandex.ru
MD, PhD Student, Chair of Skin and Venereal Diseases, Research Department of Immunodependent Dermatoses, Research Center Russian Federation

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Copyright (c) 2016 Olisova O.Y., Teplyuk N.P., Tkachenko S.B., Varshavskiy V.A., Zaydenov V.A., Allenova A.S.

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