PATHOGENIC MECHANISMS OF SEPTIC NEPHROPATHY OF THE RENAL TRANSPLANTS AND THE SEARCH FOR WAYS OF SOLVING THIS PROBLEM WITH SELECTIVE USE OF MODERN EXTRACORPOREAL METHODS

Cover Page

Cite item

Abstract

The article presents analysis of the pathogenic mechanisms of septic renal transplant nephropathy and the search for ways to solve this problem with the use of modern selective extracorporeal methods which are the most promising methods to struggle with severe septic complications and gram-negative sepsis which is a mixed-selective adsorption of endotoxin.

About the authors

М. Krstic

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Author for correspondence.
Email: fake@neicon.ru
Russian Federation

A. B. Zulkarnayev

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

A. V. Vatazin

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

E. I. Prokopenko

M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)

Email: fake@neicon.ru
Russian Federation

References

  1. Аниховская И.А., Опарина О.Н., Яковлева М.М., Яковлев М.Ю. Кишечный эндотоксин как универсальный фактор адаптации и патогенеза общего адаптационного синдрома // Физиол. чел. 2006. №2. С.87-91.
  2. Яковлев М.Ю. Кишечный липополисахарид: системная эндотоксинемия – эндотоксиновая агрессия – SIR-синдром и полиорганная недостаточность как звенья одной цепи // Бюлл. ВНЦ РАМН. 2005. №1. С.15-18.
  3. Яковлев М.Ю. Кишечный эндотоксин – SIRS – полиорганная недостаточность // Труды РОП. 2006. Т.1. С.437-440.
  4. Яковлев М.Ю. Элементы эндотоксиновой теории физиологии и патологии человека // Физиол. чел. 2003. №4. С.154-164.
  5. Antonelli M., Fumagalli R., Cruz D.N. et al. PMX endotoxin removal in the clinical practice: results from the EUPHAS trial // Contrib. Nephrol. 2010. No.167. P.83-90.
  6. Audard V., Amor M., Desvaux D. et al. Acute graft pyelonephritis: a potential cause of acute rejection in renal transplant // Transplantation. 2005. V.80, No.8. P.1128-1130.
  7. Becker S., Witzke O., Rübben H., Kribben A. Urinary tract infections after kidney transplantation: Essen algorithm for calculated antibiotic treatment // Urologe A. 2011. V.50, No.1. P.53-56.
  8. Cardoso P.G., Macedo G.C., Azevedo V., Oliveira S.C. Brucella spp. noncanonical LPS: structure, biosynthesis, and interaction with host immune system // Microb. Cell Fact. 2006. V.5. P.13.
  9. Cavaillon J.M. Polymyxin B for endotoxin removal in sepsis // Lancet Infect. Dis. 2011. V.11, No.6. P.426-427.
  10. Cruz D.N., Bellomo R., Ronco C. Clinical effects of polymyxin B-immobilized fiber column in septic patients // Contrib. Nephrol. 2007. No.156. P.444-451.
  11. Cruz D.N., Perazella M.A., Bellomo R. et al. Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review // Crit. Care. 2007. V.11, No.2. R47.
  12. Kamath N.S., John G.T., Neelakantan N. et al. Acute graft pyelonephritis following renal transplantation // Transpl. Infect. Dis. 2006. V.8, No.3. P.140-147.
  13. Linares L., Cofán F., Cervera C. et al. Infection-related mortality in a large cohort of renal transplant recipients // Transplant. Proc. 2007. V.39, No.7. P.2225-2227.
  14. Martin E.L., Cruz D.N., Monti G. et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project // Con-trib. Nephrol. 2010. No.167. P.119-125.
  15. Müller V., Becker G., Delfs M. et al. Do urinary tract infections trigger chronic kidney transplant rejection in man? // J. Urol. 1998. V.159, No.6. P.1826-1829.
  16. Nankivell B.J., Chapman J.R. Chronic allograft nephropathy: current concepts and future directions // Transplantation. 2006. V.81, No.5. P.643-654.
  17. Oguz Y., Doganci L., Bulucu F. et al. Acute pyelonephri-tis causing acute renal allograft dysfunction // Int. Urol. Nephrol. 2002. V.34, No.3. P.299-301.
  18. Pellé G., Vimont S., Levy P.P. et al. Acute pyelonephritis represents a risk factor impairing long-term kidney graft function // Am. J. Transplant. 2007. V.7, No.4. P.899-907.
  19. Pourmand G., Salem S., Mehrsai A. et al. Infectious complications after kidney transplantation: a single-center experience // Transpl. Infect. Dis. 2007. V.9, No.4. P.302-309.
  20. Sato K., Maekawa H., Sakurada M. et al. Direct hemoper-fusion with polymyxin B immobilized fiber for abdominal sepsis in Europe // Surg. Today. 2011. V.41, No.6. P.754-760.
  21. Valera B., Gentil M.A., Cabello V. et al. Epidemiology of urinary infections in renal transplant recipients // Transplant. Proc. 2006. V.38, No.8. P.2414-2415.
  22. Villar J., Maca-Meyer N., Pérez-Méndez L., Flores C. Bench-to-bedside review: understanding genetic predisposition to sepsis // Crit. Care. 2004. V.8, No.3. P.180-189.
  23. Witzke O., Schmidt C., Kohnle M. et al. Impact of febrile infections on the long-term function of kidney allografts // J. Urol. 2001. V.166, No.6. P.2048-2052.
  24. Zukowski M., Kotfis K., Biernawska J. et al. Graft infection in kidney recipients and its relation to transplanted kidney function // Transplant. Proc. 2011. V.43, No.8. P.2997-2999.

Copyright (c) 2016 Krstic М., Zulkarnayev A.B., Vatazin A.V., Prokopenko E.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies