Cirrhotic cardiomyopathy and liver transplantation

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Abstract

Cirrhotic cardiomyopathy is a syndrome, which includes systolic and diastolic dysfunction and electrophysiological abnormalities in patients with liver cirrhosis in the absence of any cardiac disease. Several mechanisms seem to be involved in the pathogenesis of cirrhotic cardiomyopathy, such as impaired signaling of beta-receptors, altered trans-membrane ion currents and excess production of vasodilators. Clinical manifestation of cirrhotic cardiomyopathy is non-specific and is usually masked by the symptoms of cirrhosis. Despite frequent regression of cirrhotic cardiomyopathy after liver transplantation, myocardial dysfunction may lead to cardiac complications during transplantation surgery and post-operatively. Severe myocardial dysfunction may affect liver transplantation outcomes with an increase in cardiovascular mortality. Therefore, timely identification of cirrhotic cardiomyopathy is crucial for assessment of candidate patients for liver transplantation. At present, there is no specific therapy for cirrhotic cardiomyopathy. Recommended treatment should be aimed at support of myocardial function and prevention of decompensation.

About the authors

Yu. O. Malinovskaya

Lomonosov Moscow State University, Moscow; Moscow Regional Research and Clinical Institute, Moscow

Author for correspondence.
Email: yumalinovskaya@gmail.com

Malinovskaya Yuliya – Postgraduate Student, Chair of Internal Diseases, Faculty of Basic Medicine, Physician, Department of Hepatology.

61/2-8 Shchepkina ul., Moscow, 129110, Russian Federation. Tel.: +7 (916) 493 36 08. E-mail: yumalinovskaya@gmail.com Russian Federation

S. V. Moiseev

Lomonosov Moscow State University, Moscow

Email: fake@neicon.ru
Moiseev Sergey V. – MD, PhD, Professor, Chair of Internal Diseases, Faculty of Basic Medicine  Russian Federation

Ya. G. Moysyuk

Moscow Regional Research and Clinical Institute, Moscow

Email: fake@neicon.ru
Moysyuk Yan G. – MD, PhD, Professor, Chief Research Fellow, Department of Abdominal Surgery Russian Federation

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