PARATHYROID CANCER OCCURRING IN RELAPSING SECONDARY HYPERPARATHYROIDISM

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Abstract

We present a clinical case of parathyroid cancer in a patient with relapsing secondary hyperparathyroidism at 4 years after subtotal parathyroidectomy. Its unique character is related to the combination of relapsing secondary hyperparathyroidism, parathyromatosis, ectopic of an adenomatous hyperplastic parathyroid gland into the thyroid gland, and parathyroid cancer. Several most complicated aspects of parathyroid surgery are disclosed, such as the choice of strategy for surgical intervention in secondary hyperparathyroidism, complexity of morphological and cytological diagnostics of this disorder.

About the authors

I. V. Kotova

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: kotovaira777@gmail.com

MD, PhD, Leading Research Fellow, Department of Endocrine Surgery,

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

I. A. Voronkova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Physician, Laboratory of Pathomorphology,

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

I. A. Kazantseva

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Head of Department of Pathological Anatomy,

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

References

  1. Schneider R, Slater EP, Karakas E, Bartsch DK, Schlosser K. Initial parathyroid surgery in 606 patients with renal hyperparathyroidism. World J Surg. 2012;36(2):318–26. doi: 10.1007/s00268-011-1392-0.
  2. Кваченюк АМ, Комисаренко ИВ, Рыбаков СИ, Коваленко АЕ. Особенности хирургического лечения рака паращитовидных желез. Клиническая эндокринология и эндокринная хирургия. 2003;(1):34–7.
  3. Akerström G, Malmaeus J, Bergström R. Surgical anatomy of human parathyroid glands. Surgery. 1984;95(1):14–21.
  4. Мальцев РВ, Евменова ТД, Осипов ЛЕ, Лотц ВИ. Опыт хирургического лечения вторичного гиперпаратиреоза у больных с терминальной почечной недостаточностью. Нефрология и диализ. 2007;9(3):275–6.
  5. Лукьянчиков ВС, Калинин АП, Нурманбетов ДН. Рак околощитовидных желез. Вопросы онкологии. 1991;37(3):266–74.
  6. Калинин АП, Нурманбетов ДН, Лукьянчиков ВС. Первичный гиперпаратиреоз. Бишкек: Илим; 1992. 242 с.
  7. Boyle NH, Ogg CS, Hartley RB, Owen WJ. Parathyroid carcinoma secondary to prolonged hyperplasia in chronic renal failure and in coeliac disease. Eur J Surg Oncol. 1999;25(1):100–3.
  8. Shane E. Clinical review 122: Parathyroid carcinoma. J Clin Endocrinol Metab. 2001;86(2): 485–93. doi: 10.1210/jcem.86.2.7207.
  9. Vetto JT, Brennan MF, Woodruf J, Burt M. Parathyroid carcinoma: diagnosis and clinical history. Surgery. 1993;114(5):882–92.
  10. Kanematsu E, Matsui H, Deguchi T, Yamamoto O, Korematsu M, Kobayashi A, Nezasa SI, Yamamoto N, Takeuchi T, Tanaka T, Kawada Y. Significance of AgNOR counts for distinguishing carcinoma from adenoma and hyperplasia in parathyroid gland. Hum Pathol. 1997;28(4):421–7. doi: http://dx.doi.org/10.1016/S0046-8177(97)90030-7.

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Copyright (c) 2016 Kotova I.V., Voronkova I.A., Kazantseva I.A.

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