EXPRESSION PROFILES AND METHYLATION GENES IN CLEAR CELL RENAL CARCINOMA

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  • Authors: Braga E.A.1,2,3, Zhinzhilo T.A.4,5, Kolpakov A.V.6,7, Mikhaylenko D.S.8,9,10, Kushlinskii N.E.11,12
  • Affiliations:
    1. Institute of General Pathology and Pathophysiology
    2. 8 Baltiyskaya ul., Moscow, 125315, Russian Federation Research Centre of Medical Genetics
    3. 1 Moskvorech'e ul., Moscow, 115478, Russian Federation
    4. Medical and Rehabilitation Center
    5. 3 Ivan'kovskoe shosse, Moscow, 125367, Russian Federation
    6. V.D. Babenko Tambov Regional Clinical Hospital
    7. 29 Moskovskaya ul., Tambov, 392000, Russian Federation
    8. Research Centre of Medical Genetics
    9. 1 Moskvorech'e ul., Moscow, 115478, Russian Federation N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center
    10. 51/1 3-ya Parkovaya ul., Moscow, 105425, Russian Federation
    11. Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
    12. 20–1 Delegatskaya ul., Moscow, 127473, Russian Federation
  • Issue: Vol 44, No 5 (2016)
  • Pages: 546-557
  • Section: REVIEW ARTICLE
  • URL: https://almclinmed.ru/jour/article/view/443
  • DOI: https://doi.org/10.18786/2072-0505-2016-44-5-546-557
  • ID: 443


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Abstract

Renal cancer (RC) is a common malignancy of the genitourinary system. Clear cell renal cell carcinoma is the most common histological type of RC. In most cases diagnosis and prognosis of clear cell renal cell carcinoma are based on the results of instrumental tests, while search for novel molecular RC markers and their characterization remain relevant. Molecular genetic abnormalities accompanied with changes in gene expression underly the RC carcinogenesis; however, diagnostic panels of the expression markers of RC are still not widely used. This review represents the results of recent research in the area of gene expression markers of RC aimed to elaborate prognostic test systems. Application of the NotI-microarray methodology allowed for identification of many novel genes associated with RC pathogenesis. The relationship of alterations of expression level and methylation of chromosome 3 genes with RC progression and metastasis has been shown. Based on this data, a  diagnostic marker system for RC have been proposed with identification of expression and methylation profiles and novel markers, that is an urgent problem in modern urologic oncology.

About the authors

E. A. Braga

Institute of General Pathology and Pathophysiology; 8 Baltiyskaya ul., Moscow, 125315, Russian Federation
Research Centre of Medical Genetics; 1 Moskvorech'e ul., Moscow, 115478, Russian Federation

Author for correspondence.
Email: biochimia@mtu-net.ru
PhD, Doctor of Biol. Sci., Professor, Head of Laboratory of Genomics and Transcriptomics Russian Federation

T. A. Zhinzhilo

Medical and Rehabilitation Center; 3 Ivan'kovskoe shosse, Moscow, 125367, Russian Federation

Email: biochimia@mtu-net.ru
MD, Specialist in Clinical Laboratory Diagnostics Russian Federation

A. V. Kolpakov

V.D. Babenko Tambov Regional Clinical Hospital; 29 Moskovskaya ul., Tambov, 392000, Russian Federation

Email: biochimia@mtu-net.ru
MD, Head of Department of Urology Russian Federation

D. S. Mikhaylenko

Research Centre of Medical Genetics; 1 Moskvorech'e ul., Moscow, 115478, Russian Federation
N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center; 51/1 3-ya Parkovaya ul., Moscow, 105425, Russian Federation

Email: biochimia@mtu-net.ru
MD, PhD, Leading Research Fellow, Department of Pathology Anatomy with the Molecular Genetic Group Russian Federation

N. E. Kushlinskii

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; 20–1 Delegatskaya ul., Moscow, 127473, Russian Federation

Email: biochimia@mtu-net.ru
MD, PhD, Professor, Member-Correspondent of Russian Academy of Sciences, Head of Chair of Clinical Chemistry and Laboratory Diagnostics Russian Federation

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