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НОВООБРАЗОВАНИЯ ПРИ АКРОМЕГАЛИИ

https://doi.org/10.18786/2072-0505-2016-44-5-568-579

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Аннотация

Акромегалия – редкое заболевание, характеризующееся повышенной секрецией соматотропного гормона, что наиболее часто обусловлено наличием аденомы гипофиза. Отсутствие своевременного лечения акромегалии ведет к  преждевременной смерти больных, связанной с  повышением частоты развития острых сердечно-сосудистых осложнений, апноэ сна, метаболических нарушений и злокачественных новообразований. Частота злокачественных новообразований при акромегалии составляет от  4,5 до  25% (при этом механизмы их развития имеют ряд отличительных особенностей),  в  9–50%  случаев они становятся причиной гибели пациентов. При акромегалии общая смертность и смертность от онкологических заболеваний коррелирует с активностью заболевания. Установлена прямая зависимость между высоким уровнем инсулиноподобного ростового фактора 1 крови и риском развития злокачественных опухолей. У больных акромегалией наиболее часто встречаются злокачественные новообразования толстого кишечника (1–20%) и  щитовидной железы (7,8–11%). В  обзоре литературы отражены результаты эпидемиологических исследований злокачественных новообразований, а также некоторые аспекты их патогенеза у больных акромегалией.

Об авторах

И. Д. Чих
ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»; 129110, г. Москва, ул. Щепкина, 61/2, Российская Федерация
Россия
заведующая отделением терапевтической эндокринологии


И. В. Триголосова
ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»; 129110, г. Москва, ул. Щепкина, 61/2, Российская Федерация
Россия
канд. мед. наук, ст. науч. сотр. отделения терапевтической эндокринологии


А. В. Древаль
ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»; 129110, г. Москва, ул. Щепкина, 61/2, Российская Федерация
Россия
д-р мед. наук, профессор, руководитель отделения терапевтической эндокринологии, заведующий кафедрой эндокринологии факультета усовершенствования врачей


А. В. Триголосов
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России; 115478, г. Москва, Каширское шоссе, 24, Российская Федерация
Россия
канд. мед. наук, ст. науч. сотр. отделения радиохирургии


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1. Fig. 1. Prevalence of malignancies in acromegaly
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2. Fig. 2. Potential contributors to the pathogenesis of colorectal cancer in acromegaly; IGF1 – insulin-like growth factor 1
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Чих И.Д., Триголосова И.В., Древаль А.В., Триголосов А.В. НОВООБРАЗОВАНИЯ ПРИ АКРОМЕГАЛИИ. Альманах клинической медицины. 2016;44(5):568-579. https://doi.org/10.18786/2072-0505-2016-44-5-568-579

For citation:


Chikh I.D., Trigolosova I.V., Dreval' A.V., Trigolosov A.V. NEOPLASMS IN ACROMEGALY. Almanac of Clinical Medicine. 2016;44(5):568-579. (In Russ.) https://doi.org/10.18786/2072-0505-2016-44-5-568-579

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ISSN 2072-0505 (Print)
ISSN 2587-9294 (Online)