MULTICHANNEL INTRALUMINAL IMPEDANCE-PH MEASUREMENT AND ITS OPPORTUNITIES IN CHILDREN WITH GASTROESOPHAGEAL REFLUX DISEASE

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Abstract

Aim: To review data from clinical studies on a multichannel intraluminal impedance-pH measurement in children with gastroesophageal reflux disease (GERD). Key points: Esophageal pH measurement is considered a golden standard of GERD diagnostics   in  children.  However,  this  method can identify only the  acid reflux. Recently, multichannel  intraluminal impedance measurement of esophagus has been  introduced into the work-up of such children. This method gives the opportunity to diagnose  liquid, gas or mixed types of reflux and to determine whether it is acid, weakly acid or basic, as well as to obtain  data  on localization of the bolus in the esophagus, its length  and direction of movement (antegrade or retrograde). We present  the information on normal parameters of multichannel  intraluminal impedance and its use for assessment of infants,  as well as on changes in its parameters in children  with apnoe  and  on clinical value of non-acid reflux. The significance of multichannel intraluminal impedance in detection of esophageal disorders in patients  with otolaryngologic  symptoms   and  other  extra-esophageal signs  is discussed. Аn association  between the results  of this method and  endoscopic  and  histological abnormalities  found in GERD patients  is being actively studied. The authors  of the review focus their attention on the  data  on changes  of multichannel  intraluminal impedance parameters during  treatment of GERD  children  with  proton pump  inhibitors. Conclusion: Multichannel intraluminal impedance is a new modern  method with wide spectrum of diagnostic opportunities.

About the authors

S. I. Erdes

I.M. Sechenov First Moscow State Medical University, Moscow

Author for correspondence.
Email: erdes@mma.ru
Erdes Svetlana I. – MD, PhD, Professor, Head of the Chair of Pediatric Propedeutics, Pediatric Faculty Russian Federation

A. R. Polishchuk

I.M. Sechenov First Moscow State Medical University, Moscow

Email: erdes@mma.ru
Polishchuk Albina R. – Assistant, Chair of Pediatric Propedeutics, Pediatric Faculty Russian Federation

I. A. Topolskova

I.M. Sechenov First Moscow State Medical University, Moscow

Email: erdes@mma.ru
Topolskova Irina A. – Assistant, Chair of Pediatric Propedeutics, Pediatric Faculty Russian Federation

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Copyright (c) 2015 Erdes S.I., Polishchuk A.R., Topolskova I.A.

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