Ichthyosis hystrix disease or verrucous epidermal nevus (a retrospective analysis of 20-year observation)

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Abstract

We present a  clinical case of ichthyosis hystrix, a rare genetic ichthyosiform dermatosis. Specifics of the disease are related to the complexity of differential diagnosis and verification of the diagnosis, because clinical manifestation of ichthyosis hystrix is similar with that of verrucous epidermal nevus. Clinical particulars of both nosologies are characterized by bizarre and widespread skin lesions of spicular hyperkeratotic growth, located along Blaschko lines. The exclusive feature of the clinical case described is a  long-term (20 years) clinical and laboratory monitoring of the patient. The literature review provides brief information on etiology, pathogenesis, clinical features, differential diagnosis, and pathomorphology of ichthyosis hystrix and verrucous epidermal nevus.

About the authors

V. D. El'kin

Perm State Medical University named after academician E.A. Vagner

Email: fake@neicon.ru

MD, PhD, Professor, Head of the Chair of Dermatovenereology,

26 Petropavlovskaya ul., Perm, 614990

Russian Federation

T. G. Sedova

Perm State Medical University named after academician E.A. Vagner

Author for correspondence.
Email: sedovca-1978@yandex.ru

MD, PhD, Associate Professor, Chair of Dermatovenereology,

26 Petropavlovskaya ul., Perm, 614990

Russian Federation

E. V. Plotnikova

Perm State Medical University named after academician E.A. Vagner

Email: fake@neicon.ru

Assistant, Chair of Dermatovenereology,

26 Petropavlovskaya ul., Perm, 614990

Russian Federation

I. D. Kuznetsov

Perm State Medical University named after academician E.A. Vagner

Email: fake@neicon.ru

MD, PhD, Associate Professor, Chair of Dermatovenereology,

26 Petropavlovskaya ul., Perm, 614990

Russian Federation

M. Yu. Novoselova

Perm State Medical University named after academician E.A. Vagner

Email: fake@neicon.ru

MD, PhD, Assistant, Chair of Dermatovenereology,

26 Petropavlovskaya ul., Perm, 614990

Russian Federation

References

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Copyright (c) 2017 El'kin V.D., Sedova T.G., Plotnikova E.V., Kuznetsov I.D., Novoselova M.Y.

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