Сurrent concepts in physiological and reparative osteogenesis

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Abstract

Studies conducted in the recent years by biologists strongly suggest that physiological and reparative osteogenesis, as well as of the functional, adaptive, and post-traumatic reconstruction of bone tissues are based on common and stereotypical molecular and cellular mechanisms. Our experimental studies have shown that all stages of the bone microstructure morphogenesis are synchronously and continuously associated with focal and stereotypical angiogenesis (capillarogenesis). A powerful factor in the implementation of reparative osteogenesis is the osteoinductive interaction of the ends of the damaged bone segments, which positively shows itself even in cases of large diastasis between the fragments (provided that the fragments are steadily fixed). After any kind of stable osteosynthesis, by ensuring the stability of the bone fragments for the entire period of consolidation, an endosteal cortical bone regeneration by direct osteogenesis (i.e. without fibro-cartilaginous tissue) is observed in the minimum amount at the shortest time period. Periosteal bone formation in this case is actually a reserve source of bone formation, which becomes effective during insufficiently stable conditions. The instability of the bone damage area particularly that of the metal implants results in the most severe destructive consequences. 

About the authors

G. A. Onoprienko

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: gao-1537@mail.ru

Onoprienko Gennadiy A. – MD, PhD, Professor, Corresponding Member of Russian Academy of Sciences, Professor of Chair of Traumatology and Orthopaedics, Postgraduate Training Faculty 

22–118 B. Gruzinskaya ul., Moscow, 123242

Russian Federation

V. P. Voloshin

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

Voloshin Viktor P. – MD, PhD, Professor; Head of Department of Traumatology and Orthopaedics, Head of Chair of Traumatology and Orthopaedics, Postgraduate Training Faculty

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

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