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Альманах клинической медицины

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Классификация, регуляция активности, генетический полиморфизм матриксных металлопротеиназ в норме и при патологии

https://doi.org/10.18786/2072-0505-2017-45-4-266-279

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Аннотация

Матриксные металлопротеиназы (ММП) – семейство цинксодержащих эндопептидаз, катализирующих реакции деградации компонентов внеклеточного матрикса. У человека известно 23 фермента этого семейства, которые подразделяют на 6 групп с учетом их структуры и типа субстрата: коллагеназы, желатиназы, стромелизины, матрилизины, ММП мембранного типа и остальные ММП. Функции ММП разнообразны, и нарушение баланса их активности может быть одним из этиологических факторов различных заболеваний. В обзоре рассмотрены классификация, регуляция активности и генетический полиморфизм ММП в норме и при различных патологических процессах в организме человека. Приведен перечень наиболее изученных в настоящее время полиморфных вариантов генов MMП, описаны их функциональные эффекты и представлены результаты ассоциативных исследований.

Об авторах

А. С. Шадрина
ФГБУН «Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук»
Россия

канд. биол. наук, мл. науч. сотр., лаборатория фармакогеномики

630090, г. Новосибирск, просп. Академика Лаврентьева, 8, Российская Федерация. Тел: +7 (383) 363 51 71



Я. З. Плиева
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России
Россия

соискатель, кафедра клинической биохимии и лабораторной диагностики

127473, г. Москва, ул. Делегатская, 20–1, Российская Федерация



Д. Н. Кушлинский
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России
Россия

канд. мед. наук, хирург-гинеколог

115478, г. Москва, Каширское шоссе, 24, Российская Федерация



А. А. Морозов
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России
Россия

соискатель, кафедра клинической биохимии и лабораторной диагностики

127473, г. Москва, ул. Делегатская, 20–1, Российская Федерация



М. Л. Филипенко
ФГБУН «Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук»
Россия

канд. биол. наук, руководитель лаборатории фармакогеномики

630090, г. Новосибирск, просп. Академика Лаврентьева, 8, Российская Федерация



В. Л. Чанг
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России
Россия

соискатель, кафедра клинической биохимии и лабораторной диагностики

127473, г. Москва, ул. Делегатская, 20–1, Российская Федерация



Н. Е. Кушлинский
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России
Россия

д-р мед. наук, профессор, чл.-корр. РАН, руководитель лаборатории клинической биохимии

115478, г. Москва, Каширское шоссе, 24, Российская Федерация



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Дополнительные файлы

1. Table 1. Human matrix metalloproteinases [2, 3, 4, 6]
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Тип Исследовательские инструменты
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2. Table 2. The most studied functional polymorphic loci in the matrix metalloproteinase genes
Тема
Тип Исследовательские инструменты
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Шадрина А.С., Плиева Я.З., Кушлинский Д.Н., Морозов А.А., Филипенко М.Л., Чанг В.Л., Кушлинский Н.Е. Классификация, регуляция активности, генетический полиморфизм матриксных металлопротеиназ в норме и при патологии. Альманах клинической медицины. 2017;45(4):266-279. https://doi.org/10.18786/2072-0505-2017-45-4-266-279

For citation:


Shadrina A.S., Plieva Y.Z., Kushlinskiy D.N., Morozov A.A., Filipenko M.L., Chang V.L., Kushlinskii N.E. Classification, regulation of activity, and genetic polymorphism of matrix metalloproteinases in health and disease. Almanac of Clinical Medicine. 2017;45(4):266-279. (In Russ.) https://doi.org/10.18786/2072-0505-2017-45-4-266-279

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