Combination treatment of parotid salivary gland cancer

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Abstract

Background: Cancer of the parotid salivary gland (PSG) accounts for more than a half of all cases of salivary gland malignancies. Its treatment strategy remains a matter of debate.

Aim: To identify factors significantly associated with the 3-year survival of patients with PSG cancer after combination treatment.

Materials and methods: Thirty nine patients with morphologically confirmed PSG cancer (T1-4N0) were recruited into the study. Surgery (partial or total parotidectomy without the cervical lymphatic node dissection) was performed in 32 patients. The most frequent diagnosis (n = 10; 25.6% of all cases) was adenocarcinoma. Radiation to PSG and the regional lymphatic nodes was used in 15 patients as neoadjuvant and in 24 as adjuvant regimen. Three-year survival rates were analyzed in 36 patients by the Kaplan-Meier method, with consideration of their sex, age and the sequence of surgical and radiation treatment.

Results: The 3-year survival after combination treatment of PSG cancer patients was 82.7%. Women, patients above 60 years of age and those who received adjuvant radiation therapy demonstrated a trend towards better 3-year survival, although it was non-significant (p > 0.05).

Conclusion: Combination strategy remains an effective approach to PSG cancer irrespective of age and sex of patients. The use of radiation therapy as a single modality is possible only in exceptional cases.

About the authors

A. S. Balkanov

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: andreybalkanov@yandex.ru

MD, PhD, Head of Department of Radiology

61/2–7 Shchepkina ul., Moscow, 129110, Russian Federation. Tel.: +7 (495) 681 19 07

Russian Federation

O. A. Bychenkov

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Senior Research Fellow, Department of Radiology

61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Russian Federation

A. M. Sipkin

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Leading Research Fellow, Oral and Maxillofacial Surgery Department

61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Russian Federation

L. E. Gaganov

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Chief of Department of Pathological Anatomy

61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Russian Federation

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Copyright (c) 2017 Balkanov A.S., Bychenkov O.A., Sipkin A.M., Gaganov L.E.

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