Email this article The influence of cholecystectomy at young age on the course of metabolic syndrome in women
- Authors: Lebedeva O.V.1, Bueverov A.O.1, Bueverova E.L.1, Nikitina L.O.2
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Affiliations:
- M. Sechenov First Moscow State Medical University
- National Medical Research Center for Rehabilitation and Curortology
- Issue: Vol 45, No 5 (2017)
- Pages: 384-391
- Section: ARTICLES
- URL: https://almclinmed.ru/jour/article/view/615
- DOI: https://doi.org/10.18786/2072-0505-2017-45-5-384-391
- ID: 615
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Abstract
Rationale: At present, the metabolic syndrome and pathophysiology of non-alcoholic fatty liver disease, as well as identification of factors that may influence the rate of development of dystrophy and fibrosis in the liver are in the focus of investigators' attention. This study represents an attempt to detail metabolic derangements and liver tissue abnormalities after cholecystectomy in patients with metabolic syndrome at baseline.
Aim: To study the influence of cholecystectomy performed at younger age on the course of metabolic syndrome in women.
Materials and methods: This was a retrospective analytical study in a sample of 57 female patients with metabolic syndrome (International Diabetes Federation criteria 2005) aged from 18 to 44 years (young age according to the World Health Organization definition). From those, 30 patients with cholelithiasis were included into the control group and 27 patients who had undergone cholecystectomy in this age range were included into the comparison group. We analyzed their past history, results of clinical examination, laboratory tests, abdominal ultrasound examination, esophagogastroduodenoscopy, hydrogen respiration test with lactulose, as well as the results of needle liver biopsy.
Results: Non-alcoholic steatohepatitis after cholecystectomy was associated with the excessive bacterial growth in the small intestine (р = 0.026), ultrasound signs of cholangitis (р = 0.041), and diarrhea syndrome (р = 0.027). Liver fibrosis was significantly more frequent in association with chronic diarrhea (р = 0.034) and past clinical signs of post-cholecystectomy syndrome (р = 0.044). There was a strong direct correlation between the grade of fibrosis and the time since cholecystectomy (r = 0.77; р = 0.047).
Conclusion: Cholecystectomy performed at young age predicts progression of metabolic abnormalities in women with metabolic syndrome.
About the authors
O. V. Lebedeva
M. Sechenov First Moscow State Medical University
Author for correspondence.
Email: ovgastro@mail.ru
Lebedeva Ol'ga V. – Postgraduate Student, Chair of Medical and Social Expert Assessment and Out-Patient Therapy, Postgraduate Medical Training Faculty.
2/1–41 Kustanayskaya ul., Moscow, 115580, +7 (916) 989 05 95
Russian FederationA. O. Bueverov
M. Sechenov First Moscow State Medical University
Email: fake@neicon.ru
Bueverov Aleksey O. – MD, PhD, Professor, Chair of Medical and Social Expert Assessment and Out-Patient Therapy, Postgraduate Medical Training Faculty.
8/2 Trubetskaya ul., Moscow, 119991
Russian FederationE. L. Bueverova
M. Sechenov First Moscow State Medical University
Email: fake@neicon.ru
Bueverova Elena L. – MD, PhD, Assistant Professor, Chair for Propaedeutics of Internal Diseases, Medical Faculty.
8/2 Trubetskaya ul., Moscow, 119991
Russian FederationL. O. Nikitina
National Medical Research Center for Rehabilitation and Curortology
Email: fake@neicon.ru
Nikitina Liliana O. – MD, PhD, Vice-chancellor for Postgraduate and Complementary Training.
32 Novyy Arbat ul., Moscow, 121099
Russian FederationReferences
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