Email this article A clinical case of hereditary thrombophilia in a patient with ulcerative colitis
- Authors: Fadeeva N.A.1, Donchenko I.A.1, Knyazev O.V.1, Lishchinskaya A.A.1, Dudina G.A.1, Ruchkina I.N.1, Subbotin V.V.1, Noskova K.K.1, Rogozina V.A.1, Parfenov A.I.1
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Affiliations:
- Moscow Clinical Scientific Center, Moscow Healthcare Department
- Issue: Vol 45, No 5 (2017)
- Pages: 423-428
- Section: CLINICAL CASES
- URL: https://almclinmed.ru/jour/article/view/619
- DOI: https://doi.org/10.18786/2072-0505-2017-45-5-423-428
- ID: 619
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Abstract
We present a clinical case of a 24-year old female patient who was hospitalized with high active ulcerative colitis associated with latent hereditary thrombophilia uncontrolled due to the exacerbation of ulcerative colitis and local steroid treatment. The patient was treated with combination of systemic steroids, adalimumab and anticoagulants. We emphasize the necessity of the multidisciplinary approach to her treatment. The clinical case demonstrates the possibility of safe use of anticoagulants to prevent thromboembolic complications in patients with ulcerative colitis and high risk of thrombus formation, under careful monitoring of coagulation parameters and thromboelastography. We discuss the need in clear guidelines to determine treatment strategy for patients with inflammatory bowel diseases, coagulopathies and thromboembolic complications.
About the authors
N. A. Fadeeva
Moscow Clinical Scientific Center, Moscow Healthcare Department
Author for correspondence.
Email: chuevana@mail.ru
Fadeeva Nina A. – MD, PhD, Senior Research Fellow, Department of Inflammatory Bowel Diseases.
86 Shosse Entuziastov, Moscow, 111123, +7 (926) 484 85 90
Russian FederationI. A. Donchenko
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Donchenko Irina A. – MD, Gastroenterologist, Department of Inflammatory Bowel Diseases.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationO. V. Knyazev
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Knyazev Oleg V. – MD, PhD, Head of Department of Inflammatory Bowel Diseases.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationA. A. Lishchinskaya
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Lishchinskaya Al'bina A. – MD, PhD, Senior Research Fellow, Department of Inflammatory Bowel Diseases.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationG. A. Dudina
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Dudina Galina A. – MD, PhD, Senior Research Fellow, Department of Oncohematology.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationI. N. Ruchkina
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Ruchkina Irina N. – MD, PhD, Leading Research Fellow, Department of Inflammatory Bowel Diseases.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationV. V. Subbotin
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Subbotin Valeriy V. – MD, PhD, Head of Center of Anesthesiology and Intensive Care.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationK. K. Noskova
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Noskova Karina K. – MD, PhD, Head of Laboratory.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationV. A. Rogozina
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Rogozina Vera A. – MD, Endoscopist, Diagnostic Endoscopy Department.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationA. I. Parfenov
Moscow Clinical Scientific Center, Moscow Healthcare Department
Email: fake@neicon.ru
Parfenov Asfold I. – MD, PhD, Professor, Head of Department of Bowel Diseases.
86 Shosse Entuziastov, Moscow, 111123
Russian FederationReferences
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