The role of hypoxia-induced factor in the regulation of oxygen homeostasis during reparative regeneration in compromised microcirculation

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Abstract

The aim of the present review is to find an answer to the clinically important question on the mechanisms regulating the activity of reparative regeneration in hypoxic conditions and potential ways to modify this process. In the recent studies, compensated hypoxia is characterized as a trigger for the regeneration, with the central regulating factor being the member of the cytokine family, hypoxia-inducible factor-1 (HIF-1). Changes in the concentration of this protein modulates cell migration, angiogenesis and epithelialmesenchymal integration; it also stimulates the proliferation of endothelial cells and fibroblasts, playing a  major role in the stimulation of wound healing, especially with compromised microcirculation, for example, diabetes mellitus.

 

About the authors

S. G. Izmaylov

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Professor, Chair of Surgical Diseases Russian Federation

V. V. Beschastnov

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Associate Professor, Chair of Surgical Diseases Russian Federation

M. G. Ryabkov

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Professor, Chair of Surgical Diseases Russian Federation

A. E. Leont'ev

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Associate Professor, Chair of Surgical Diseases Russian Federation

E. E. Lukoyanychev

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Associate Professor, Chair of Surgical Diseases Russian Federation

M. V. Bagryantsev

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Author for correspondence.
Email: maks-bagryancev@mail.ru
PhD Student, Chair of Surgical Diseases Russian Federation

N. Yu. Orlinskaya

Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Professor, Chair of Pathological Anatomy Russian Federation

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Copyright (c) 2017 Izmaylov S.G., Beschastnov V.V., Ryabkov M.G., Leont'ev A.E., Lukoyanychev E.E., Bagryantsev M.V., Orlinskaya N.Y.

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