THE DEVELOPMENT OF DIAGNOSTICS AND ALIMENTARY PREVENTION SYSTEM OF NON-COMMUNICABLE DISEASES

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Abstract

Background: Violation of dietary intake structure leads to changes in nutritional status. This contributes to the development of non-communicable diseases, which account for more than half of causes of death inRussia.

 Materials and methods: In a consultative and diagnostic center "Healthy Nutrition" of theInstituteofNutritionthe nutritional status of 3580 patients (mean age 48.4±0.3  years) has been examined, including genomic and post-translational analysis. 30.0% of patients were overweight and 34.1% were obese.

Results: Analysis of actual dietary intake showed an increase in energy intake due to excess intake of total (44.2%  energy) and saturated fat (13.6%). Serum biochemistry analyses revealed increased cholesterol levels in 68.7%  of patients, increased low-density lipoprotein cholesterol in 63.9%, increased triglycerides in 22.5%, and increased blood glucose in 29.4%. The frequencies of risk alleles of genes associated with development of obesity and type 2 diabetes mellitus were as follows: 47.8% for the polymorphism rs9939609 (FTO gene), 8.3% for the polymorphism rs4994 (gene ADRB3), 60.2% for the polymorphism rs659366 (gene UCP2), 36.6% for the rs5219  polymorphism in the gene of ATPdependent potassium channel.

Conclusion: These results can be used for development of a personalized diet based on assessment of a patient's nutritional status. 

About the authors

A. V. Pogozheva

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Author for correspondence.
Email: allapogozheva@yandex.ru

Pogozheva Alla Vladimirovna – MD, PhD, Professor, Leading Research Fellow, Laboratory of Nutritional Epidemiology and Genodiagnostics of Noncommunicable Diseases with the group of consultative and diagnostic center "Healthy nutrition"

* 2/14 Ust'inskiy proezd, Moscow, 109240, Russian Federation. Tel.: +7 (495) 698 53 80. E-mail: allapogozheva@yandex.ru

Russian Federation

E. Yu. Sorokina

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Sorokina Elena Yur'evna – PhD, Leading Research Fellow, Laboratory of Nutritional Epidemiology and Genodiagnostics of Noncommunicable Diseases with the group of consultative and diagnostic center "Healthy nutrition" Russian Federation

A. K. Baturin

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Baturin Aleksandr Konstantinovich – MD, PhD, Professor, Deputy Directo culty Russian Federation

E. V. Peskova

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Peskova Elena Vasil'evna – Junior Research Fellow, Laboratory of Nutritional Epidemiology and Genodiagnostics of Noncommunicable Diseases with the group of consultative and diagnostic center "Healthy nutrition" Russian Federation

O. N. Makurina

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Makurina Ol'ga Nikolaevna – Junior Research Fellow, Laboratory of Nutritional Epidemiology and Genodiagnostics of Noncommunicable Diseases with the group of consultative and diagnostic center "Healthy nutrition" Russian Federation

L. G. Levin

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Levin Leonid Georgievich – PhD, Senior Research Fellow, Laboratory of proteomic and metabolomic analysis Russian Federation

T. V. Aristarkhova

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Aristarkhova Tat'yana Vladimirovna – Research Associate, Fellow, Laboratory of proteomic and metabolomic analysis Russian Federation

M. M. Korosteleva

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Korosteleva Margarita Mikhaylovna – PhD, Senior Research Fellow, Laboratory of Sport Nutrition with the group of alimentary-related disorders Russian Federation

N. N. Denisova

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Denisova Natal'ya Nikolaevna – Research Fellow, Laboratory of Nutritional Epidemiology and Genodiagnostics of Noncommunicable Diseases with the group of consultative and diagnostic center "Healthy nutrition" Russian Federation

T. N. Solntseva

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Solntseva Tat'yana Nikolaevna – PhD, Research Fellow, Laboratory of Sport Nutrition with the group of alimentary-related disorders Russian Federation

L. V. Aleshina

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Aleshina Irina Vladimirovna – Junior Research Fellow, Laboratory of Age-related Nutriciology Russian Federation

M. A. Toboleva

Scientific Research Institute of Nutrition, Russian Academy of Sciences, Moscow

Email: fake@neicon.ru
Toboleva Marina Aleksandrovna – Junior Research Fellow, Laboratory of Age-related Nutriciolog Russian Federation

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Copyright (c) 2015 Pogozheva A.V., Sorokina E.Y., Baturin A.K., Peskova E.V., Makurina O.N., Levin L.G., Aristarkhova T.V., Korosteleva M.M., Denisova N.N., Solntseva T.N., Aleshina L.V., Toboleva M.A.

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