THE MOLECULAR PATHOGENESIS OF BLADDER CANCER

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Abstract

The review describes the current views on urothelial carcinoma carcinogenesis. Based on the up-todate genetic studies, molecular pathways determining the development of superficial and invasive bladder cancers are considered. It was demonstrated that the development of noninvasive bladder tumors occurred predominantly through oncogenes activation, while the genesis of invasive cancer is based on inactivation of tumor suppressor genes. Principal mechanisms of multiple and recurrent bladder tumors development are discussed including its monoclonal and oligoclonal models.
One of the most promising nowadays approaches is the determination of new generation markers, such as molecular genetic abnormalities in the hereditary apparatus of the cell underlying its malignant transformation. Molecular markers' panels used for diagnostics, prognosis, and monitoring of urothelial carcinoma patients are analyzed.

About the authors

M. V. Nemtsova

Research Centre for Medical Genetics, Moscow

Author for correspondence.
Email: kne3108@gmail.com
Nemtsova Marina Vyacheslavovna – Doctor of Biol. Sci., Professor, Leading Research Fellow, Laboratory Epigenetics Russian Federation

N. E. Kushlinskii

N.N. Blokhin Russian Cancer Research Center, Moscow

Email: kne3108@gmail.com
Kushlinskii Nikolay Evgen'evich – MD, PhD, Professor, Member-Correspondent of Russian Academy of Sciences, Head of Clinical Biochemistry Laboratory Russian Federation

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Copyright (c) 2015 Nemtsova M.V., Kushlinskii N.E.

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