Email this article Relapse of the pituitary adenoma with a change of its hormonal activity in a female patient with multiple endocrine neoplasia syndrome type 1
- Authors: Rozhinskaya L.Y.1, Khandaeva P.M.1, Lutsenko A.S.1, Lapshina A.M.1, Grigor'ev A.Y.1, Arapova S.D.1, Belaya Z.E.1, Mel'nichenko G.A.1
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Affiliations:
- Endocrinology Research Center
- Issue: Vol 46, No 3 (2018)
- Pages: 270-275
- Section: CLINICAL CASES
- URL: https://almclinmed.ru/jour/article/view/829
- DOI: https://doi.org/10.18786/2072-0505-2018-46-3-270-275
- ID: 829
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Abstract
Multiple endocrine neoplasia syndrome type 1 (MEN1, Wermer's syndrome) is a group of heterogeneous inherited diseases, with its pathogenesis related to hyperplasia or neoplasms of several endocrine glands. This syndrome is characterized by autosomal dominant mode of inheritance, high penetrance and similar prevalence among males and females. Prevalence of MEN1 is estimated to be 1:100,000 of the population. An interesting feature of the presented clinical case is a relapse and transformation of pituitary tumor from a prolactin-secreting into the mixed one, with distinct compartments of ACTH- and prolactin-secreting, in a female patient with a family MEN1 syndrome, with involvement of the pancreas, parathyroid and pituitary glands. Her brother had a synchronous manifestation of the same types of tumors, except corticotropinoma. The presented clinical case highlights the necessity of a comprehensive and life-long follow-up of MEN1 patients for a timely detection of neoplasms and appropriate treatment.
About the authors
L. Ya. Rozhinskaya
Endocrinology Research Center
Email: fake@neicon.ru
Liudmila Yа. Rozhinskaya – MD, PhD, Professor, Chief Research Fellow, Department of Neuroendocrinology and Osteopathy.
11 Dmitriya Ul'yanova ul., Moscow, 117036
Russian FederationP. M. Khandaeva
Endocrinology Research Center
Author for correspondence.
Email: pati_khandaeva@mail.ru
Patimat M. Khandaeva – MD, Research Fellow, Department of Neuroendocrinology and Osteopathy.
11 Dmitriya Ul'yanova ul., Moscow, 117036, tel.: +7 (906) 713 11 91
Russian FederationA. S. Lutsenko
Endocrinology Research Center
Email: fake@neicon.ru
Alexander S. Lutsenko – MD, Research Fellow, Department of Neuroendocrinology and Osteopathy.
11 Dmitriya Ul'yanova ul., Moscow, 117036
Russian FederationA. M. Lapshina
Endocrinology Research Center
Email: fake@neicon.ru
Anastasiya M. Lapshina – MD, PhD, Pathoanatomist, Department of Fundamental Pathomorphology.
11 Dmitriya Ul'yanova ul., Moscow, 117036
Russian FederationA. Yu. Grigor'ev
Endocrinology Research Center
Email: fake@neicon.ru
Andrey Yu. Grigor'ev – MD, PhD, Head of Department of Neurosurgery.
11 Dmitriya Ul'yanova ul., Moscow, 117036
Russian FederationS. D. Arapova
Endocrinology Research Center
Email: fake@neicon.ru
Svetlana D. Arapova – MD, Leading Research Fellow, Department of Neuroendocrinology and Osteopathy.
11 Dmitriya Ul'yanova ul., Moscow, 117036
Russian FederationZh. E. Belaya
Endocrinology Research Center
Email: fake@neicon.ru
Zhanna E. Belaya – MD, PhD, Chief Research Fellow, Head of Department of Neuroendocrinology and Osteopathy.
11 Dmitriya Ul'yanova ul., Moscow, 117036
Russian FederationG. A. Mel'nichenko
Endocrinology Research Center
Email: fake@neicon.ru
Galina A. Mel'nichenko – Member of Russ. Acad. Sci., MD, PhD, Professor, Director of Institut of Clinical Endocrinology, Deputy Director.
11 Dmitriya Ul'yanova ul., Moscow, 117036
Russian FederationReferences
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