Kaposi’s sarcoma with the eyelid involvement (6 clinical cases)

Cover Page

Cite item

Abstract

Kaposi's sarcoma is a multifocal tumor from vascular endothelium with a low grade of malignancy. It develops due to underlying immune deficiency and is associated with human herpesvirus 8. Kaposi's sarcoma of the eyelids is rare, and its diagnosis can be difficult both for ophthalmologists and oncodermatologists. The paper describes six clinical cases of Kaposi's sarcoma with involvement of the eyelids. Three patients had an HIV-associated type of the tumor. One patient had an immunosuppressive type of the tumor during immunosuppressive treatment after kidney transplantation. Two elderly patients had Kaposi's sarcoma of the classic type. Tumors of the eyelids developed after several years of skin involvement. All patients had advanced (nodular) stage of Kaposi's sarcoma of the eyelids, whereas the skin tumors looked as spots (maculas) or papules (macular or papular stage of the disease). The eyelid tumor presented as an extensive dark red tumor nodule distinctly separate from the adjacent tissues. In all cases, the eyelid tumor was big and hindered the sight. All the patients were treated by an oncodermatologist and/or a specialist in infectious diseases, depending on the clinical type of the disease. Kaposi's sarcoma rarely involves the eyelid skin or conjunctiva; however, in immunodeficient patients it must be included into the list for the differential diagnosis of eyelid tumors.

About the authors

E. E. Grishina

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: eyelena@mail.ru

Elena E. Grishina – MD, PhD, Professor, Leading Research Fellow, Ophthalmology Department  

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

References

  1. Кубанова АА, ред. Дерматовенерология: клинические рекомендации. М.: ГЭОТАР-Медиа; 2006. 320 с.
  2. Antman K, Chang Y. Kaposi's sarcoma. N Engl J Med. 2000;342(14): 1027–38. doi: 10.1056/NEJM200004063421407.
  3. Беляков НА, Рахманова АГ, ред. Вирус иммунодефицита человека – медицина. Руководство для врачей. 2-е изд. СПб.: Балтийский образовательный центр; 2011. 655 с.
  4. Рассохин ВВ, Крестьянинова АР. Саркома Капоши. Диагностика и лечение. Практическая онкология. 2012;13(2): 114–24.
  5. Curtis TH, Durairaj VD. Ophthalmic Plast Reconstr Surg. 2005;21(4): 314–5. doi: 10.1097/01.iop.0000167783.06103.da.
  6. Bavishi A, Ashraf A, Lee L. AIDS-associated Kaposi's sarcoma of the conjunctiva in a woman. Int J STD AIDS. 2012;23(3): 221–2. doi: 10.1258/ijsa.2009.009144.
  7. Schmid K, Wild T, Bolz M, Horvat R, Jurecka W, Zehetmayer M. Kaposi's sarcoma of the conjunctiva leads to a diagnosis of acquired immunodeficiency syndrome. Acta Ophthalmol Scand. 2003;81(4): 411–3. doi: 10.1034/j.16000420.2003.00105.x.
  8. Молочков АВ, Казанцева ИА, Гурцевич ВЭ. Саркома Капоши. М.: Бином; 2002. 144 с.
  9. Dammacco R, Lapenna L, Giancipoli G, Piscitelli D, Sborgia C. Solitary eyelid Kaposi sarcoma in an HIV-negative patient. Cornea. 2006;25(4): 490–2. doi: 10.1097/01.ico.0000214212.37447.58.
  10. Kaposi M. Idiopathisces multiples Pigmentsarkom der Haut. Arch Dermatol Syph. 1872;3:265–73.
  11. Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, Sage DR, Libermann T, Dezube BJ, Fingeroth JD, Detmar M. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet. 2004;36(7): 683–5. doi: 10.1038/ng1383.
  12. Gramolelli S, Schulz TF. The role of Kaposi sarcomaassociated herpesvirus in the pathogenesis of Kaposi sarcoma. J Pathol. 2015;235(2): 368–80. doi: 10.1002/path.4441.
  13. Radu O, Pantanowitz L. Kaposi sarcoma. Arch Pathol Lab Med. 2013;137(2): 289–94. doi: 10.5858/arpa.2012-0101-RS.
  14. Orenstein JM. Ultrastructure of Kaposi sarcoma. Ultrastruct Pathol. 2008;32(5): 211–20. doi: 10.1080/01913120802343871.
  15. Ciufo DM, Cannon JS, Poole LJ, Wu FY, Murray P, Ambinder RF, Hayward GS. Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures. J Virol. 2001;75(12): 5614– 26. doi: 10.1128/JVI.75.12.5614-5626.2001.

Supplementary files

There are no supplementary files to display.


Copyright (c) 2018 Grishina E.E.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies