No 34 (2014)

ИСТОРИЯ МОНИКИ

HISTORY OF THE DERMATOVENEREOLOGY AND DERMATO-ONCOLOGY CLINIC OF THE MOSCOW REGIONAL RESEARCH AND CLINICAL INSTITUTE (MONIKI)

Molochkov V.A., Molochkov A.V., Onoprienko G.A., Romanenko G.F.

Abstract

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Almanac of Clinical Medicine. 2014;(34):6-8
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DERMATOLOGY

DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF AUTOIMMUNE PEMPHIGUS

Makhneva N.V., Davidenko E.B., Beletskaya L.V.

Abstract

Autoimmune pemphigus is a severe, potentially fatal disease affecting skin and mucous membranes. It is characterized by the presence of IgGautoantibodies against target desmosomal antigens of stratified squamous epithelium. Despite the promising results of the molecular biological research in the area of the pathogenesis of autoimmune pemphigus during past decades, diagnosis/ differential diagnosis of pemphigus remains one of the most important problems of dermatology due to rapid progression and expansion of the skin and mucous membranes lesions and the high risk of disability and death in inadequately treated patients. Correct and timely diagnosis of autoimmune pemphigus contributes to proper treatment and reduces complications risk.
Almanac of Clinical Medicine. 2014;(34):9-14
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CLINICAL EFFICACY OF EXTRA-CORPOREAL PHOTOCHEMOTHERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS

Molochkov A.V., Kil’dyushevskiy A.V., Karzanov O.V., Bagapsh L.S.

Abstract

Aim: To assess clinical efficacy of extracorporeal photochemotherapy in patients with systemic lupus erythematosus (SLE). Materials and methods: 30 SLE patients were thoroughly examined. 16 of them received medical treatment and extracorporeal photochemotherapy (treatment group), 14 patients  – routine therapy only (controls). Extracorporeal photochemotherapy involved administration of 8-methoxypsoralen 0.6 mg/kg 1.5–2 hours before the initiation of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. Cell suspension was exposed to UV-radiation (λ=320– 400 nm) using blood irradiator Julia (10–15 ml/min) during 30 minutes then re-infused. In total, 4 procedures were conducted every other day. Results: After 3 courses of extracorporeal photochemotherapy, effect (reduced eruptions) was obtained in 14 patients (46.7%). Then, the patients underwent maintenance photochemotherapy 2–3 times a year. Conclusion: Extracorporeal photochemotherapy was effective in the treatment of SLE. Immunological studies have demonstrated pathogenetic effects of extracorporeal photochemotherapy.
Almanac of Clinical Medicine. 2014;(34):15-19
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TREATMENT OF PSORIASIS WITH HOMEOPATHIC MEDICINES

Molochkov V.A.

Abstract

Background: Psoriasis is a disease with growing incidence predominantly affecting young and middle-aged patients. It is characterized by frequent exacerbations, insufficient efficacy of the routine therapy and common adverse effects. Thus, use of alternative therapies is of great importance. Aim: To assess efficacy and safety of homeopathic medicine Loma Lux Psoriasis in patients with different forms of psoriasis. Materials and methods: 45 patients with progressive (n=17) and stable (n=28) psoriasis and mean PASI (Psoriasis Area and Severity Index) value 17.3 (5–30) were treated with homeopathic medicine Loma Lux Psoriasis in combination with topical medicines: salicylic Vaseline 2%, tar and naphthalane preparations, ointments with fluocinolone acetonide and mometasone, betametasone/salicylic acid combinations. Diet was also recommended. Results: After 12 weeks, significant improvement (PASI decrease 75–100%) was demonstrated in 40%  of the patients including completely absent skin desquamation, resorption of psoriatic papules and patches with residual hyper- or depigmentation. 57.8% of the patient had moderate improvement (PASI decrease 25–75%). In one patient with only slight improvement (PASI decrease less than 25%) treatment was prolonged for 4  weeks and significant improvement was achieved. Therapy was well tolerated in all patients. No side effects or treatment-related complications were reported. Clinical recover was associated with marked tendency to improvement of blood biochemistry and immunology: elevation of immunoregulatory index up to 1.6 and T-helpers content up to 44.3%. Conclusion: Homeopathic medicine Loma Lux Psoriasis is characterized by good efficacy and safety profile and may be recommended as addon to comprehensive treatment of stable and progressing psoriasis.
Almanac of Clinical Medicine. 2014;(34):20-25
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REVISITING THE DIAGNOSIS OF PSORIATIC ARTHRITIS IN PATIENTS WITH PSORIASIS

Yakubovskaya E.S.

Abstract

Aim: To study clinical and x-ray characteristics of psoriatic arthritis in patients with psoriasis during hospital treatment in the Dermatovenereology and Dermato-Oncology Department of the Moscow Regional Research and Clinical Institute (MONIKI). Materials and methods: We examined 70  patients with generalized psoriasis vulgaris and clinically suspected or definitely diagnosed psoriatic arthritis. Functional insufficiency, characteristics, activity and radiological stage of joint disease were estimated. Results: Usually, patients with psoriasis had oligoor polyarthritis which was rarely associated with psoriatic ankylosing spondylitis and more commonly associated with peripheral arthritis. Only 6% of the patients had isolated arthralgia. Conclusion: In patients with psoriasis, psoriatic arthritis may manifest as arthralgia or low-activity arthritis without radiological signs. Thus, early detection of the disease is of importance.
Almanac of Clinical Medicine. 2014;(34):26-29
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LASER-INDUCED THERMOTHERAPY AND PHOTODYNAMIC THERAPY IN DERMATOLOGY: OPPORTUNITIES AND FUTURE HORIZONS

Molochkov A.V., Romanko Y.S., Кazantseva K.V., Sukhova T.E., Popuchiev V.V., Tret’yakova E.I., Matveeva O.V., Kuntsevich Z.S., Molochkova Y.V., Prokof’ev A.A., Dibirova S.D.

Abstract

The article reviews current data on the mechanisms of effects of laser radiation on the body, technical aspects of using different intensities of laser radiation and the effects of the laser on biological tissue. The results of studies of laser radiation as a part of comprehensive treatment of skin diseases including skin tumors are presented. Data on the efficacy and safety of laser therapy are discussed. Benefits of laser therapy in dermatology include shortening of treatment duration and only limited contraindications. Considering effectiveness, usability and safety of the method, it is regarded as a promising direction in dermatology.
Almanac of Clinical Medicine. 2014;(34):30-35
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DERMATO-ONCOLOGY

ERUPTIVE KERATOACANTHOMA OF GRZYBOWSKI

Molochkov V.A., Kuntsevich Z.S., Bobrov M.A., Dibirova S.A.

Abstract

The article presents a case of a very rare disorder – generalized eruptive keratoacanthoma of Grzybowski in a woman aged 82 years old. The disease is characterized by sudden emergence of hundreds or thousands of neoplasms (2–5 cm in diameters) rapidly spreading throughout the body skin. It is frequently associated with internistic cancer. In this case, generalized eruptive keratoacanthoma of Grzybowski was diagnosed 4 years after the disease onset. The authors emphasize the role of proper diagnosis and treatment of this pathology. Aromatic retinoids were highly effective in the therapy of generalized eruptive keratoacanthoma of Grzybowski.
Almanac of Clinical Medicine. 2014;(34):36-41
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MULTIPLE MALIGNANT TUMORS IN 8-YEARS OLD BOY WITH XERODERMA PIGMENTOSUM: A CASE REPORT

Al’banova V.I.

Abstract

This case report describes xeroderma pigmentosum in an 8-year old boy. At the age of 4 he was diagnosed with aggressive keratinizing squamous cell carcinoma. Surgical treatment, close-focus radiotherapy, isotretinoin and cyclosporine were ineffective. At the age of 8 he had multiple tumors on the face and concha of the ear, with destruction of adjacent bone and cartilage and regional nodal metastasing.
Almanac of Clinical Medicine. 2014;(34):42-46
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BENIGN EPITHELIAL NEOPLASIA ASSOCIATED WITH BETA-HUMAN PAPILLOMA VIRUS

Molochkov V.A., Korneva L.V., Snarskaya E.S., Shcherbakova E.O., Polyanskaya A.A., Nodel’man E.K.

Abstract

Aim: To study an association between acrochordon and human papilloma virus (HPV) using quantitative analysis of viral desoxyribonucleic acid (DNA); to detect different phenotypes of beta-HPV. Materials and methods: We examined 52  patients (22 immuno-suppressed patients and 30 immunocompetent subjects) in the Dermatovenereology and Dermato-Oncology Department and Chronic Dialysis and Kidney Transplantation Department of the Moscow Regional Research and Clinical Institute (MONIKI). Control group included 49 healthy donors. Burr biopsy samples (micro-samples) of acrochordon and intact skin (apper arm) were collected in sterile conditions. After sample procession and DNA isolation using DNK-sorb-C kit (Central Research Institute for Epidemiology – CRIE), polymerase chain reaction for HPV was performed with real-time fluorescent hybridization detection. For DNA amplification and detection we used RotorGene 3000 analyzer (Corbett Research, Australia). In the beta-HPV assay, recombinant plasmids were used as positive controls and control human beta-globin gene fragments (CRIE). 4 oligo-nucleotide systems (group-specific primers and probes) were used for the detection of beta-HPV DNA. Results: Preliminary data indicated that acrochordons of open and covered skin regions were common in renal transplant recipients. Beta-HPV DNA was more frequent in acrochordons and intact skin (64% and 54%) of renal transplant recipients compared to healthy donors (47%). 57% of renal transplant recipients demonstrated mixed infection in acrochordons. Conclusion: HPV DNA was frequently detected in acrochordons and intact skin of renal transplant recipients. In immunocompetent patients prevalence of HPV DNA in acrochordons was significantly higher compared to intact skin.
Almanac of Clinical Medicine. 2014;(34):47-51
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ASSOCIATION OF SEBORRHEIC KERATOSIS AND HUMAN PAPILLOMA VIRUS IN IMMUNE-SUPPRESSED AND IMMUNOCOMPETENT PATIENTS: A COMPARISON STUDY

Molochkov V.A., Korneva L.V., Snarskaya E.S., Shcherbakova E.O., Polyanskaya A.A., Trofimova O.B.

Abstract

Aim: To study an association between seborrheic keratosis and human papilloma virus (HPV) using quantitative analysis of viral desoxyribonucleic acid (DNA); to assess prevalence of different phenotypes of beta-HPV. Materials and methods: We examined 60 renal transplant recipients (20 of them had multiple seborrheic keratosis) and 22 immunocompetent patients with seborrheic keratosis. Control group included 49 healthy subjects. Burr biopsy samples (micro-samples) were collected in sterile conditions. After sample procession and DNA isolation using DNK-sorb-C kit (Central Research Institute for Epidemiology – CRIE), polymerase chain reaction for HPV was performed with real-time fluorescent hybridization detection. For DNA amplification and detection we used RotorGene 3000 analyzer (Corbett Research, Australia). In the beta-HPV assay, recombinant plasmids were used as positive controls and control human beta-globin gene fragments (CRIE). 4 oligo-nucleotide systems (group-specific primers and probes) were used for the detection of beta-HPV DNA. Results: Keratotic lesions of open and covered skin regions were common in renal transplant recipients. Beta-HPV DNA was more frequent in seborrheis keratomas and intact skin (81% and 55%) of renal transplant recipients compared to healthy donors (47%). Conclusion: HPV DNA was frequently detected in keratotic lesions and intact skin of renal transplant recipients. In immunocompetent patients prevalence of HPV DNA in keratotic lesions was significantly higher compared to intact skin.
Almanac of Clinical Medicine. 2014;(34):52-55
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PHOTODYNAMIC THERAPY IN PATIENTS WITH DIFFERENT CLINICAL FORMS OF BASAL CELL CARCINOMA OF THE SKIN

Matveeva O.V., Sukhova T.E., Tret’yakova E.I.

Abstract

Background: Photodynamic therapy is frequently applied for non-invasive destruction of basal cell carcinomas (BCC) of the skin; though, there is lack of evidence for efficacy of the method. Aim: To assess objective response of BCCs to photodynamic therapy with intralesional administration of photosensitizer Radachlorin in patients with different clinical forms, stages, flow patterns and localization of BCC. Materials and methods: 45  stage I–II BCCs patients with primary and recurrent solitary (ulcerative, superficial, scleroderma-like and nodular forms) and multiple lesions (predominantly Т₁– Т₂N₀M₀), with difficult to treat localization and high risk of recurrence were included during the period from March 2004 to March 2007. All patients received one cycle of photodynamic therapy with intralesional Radachlorin (0.5–1  ml/1  cm² tumor surface) and irradiation dose 300  J/cm² (wavelength 662 nm). A primary outcome measure was grade of clinical and cytological lesion regression after three months. Secondary outcome measure was stable clinical and cytological reaction at the lesion site. In the long-term, lesion recurrence was assessed yearly during 5 years. Results: Complete regression of BCCs was found in 43  (95.5%) patients and 47  (95.9%) lesions. In 2 (4.5%) patients with partial regression of 2 (4.1%) lesions repeated cycles of photodynamic therapy resulted in complete response. In BCCs Т₁N₀M₀, early outcome was independent from the clinical form of the diseases; by contrast, in BCCs Т₂N₀M₀, treatment of scleroderma-like BCCs was non-significantly less effective (66.7%) compared to nodular, surface (100% for both) and ulcerative (92.8%) forms. In the long-term, 1  tumor recurrence was observed after 29 months at the site of completely regressed ulcerative lesion. Conclusion: Photodynamic therapy with intralesional administration of photosensitizer Radachlorin is an effective treatment method for different clinical forms of BCC.
Almanac of Clinical Medicine. 2014;(34):56-59
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EGALLOHIT GEL IN PATIENTS WITH LASER-INDUCED THERMOTHERAPY OF SUPERFICIAL AND MICRONODULAR BASALIOMA

Tret’yakova E.I., Sukhova T.E., Matveeva O.V.

Abstract

Background: In basalioma, facial skin is frequent- E-mail: mmacosmetology@mail.ru ly affected. Thus, good cosmetological effect of treatment and anti-tumor efficacy are both important. Optimal approach includes prevention of pathological scarring. In many cases, preventive measures ensure normal scarring even after invasive methods of treatment. Aim: To assess efficacy and safety of Egallohit gel and its effects on scarring in patients with laser-induced thermotherapy (LITT) of basalioma. Materials and methods: 42 patients with superficial and micronodular basaliomas were included. LITT is a new highly effective and less invasive method providing satisfactory cosmetic results. Comprehensive treatment involved LITT (1 or 2 cycles) with subsequent application of Egallohit gel (up to 30 days after the intervention). Results: After the first LITT, clinical cure of basalioma was demonstrated in 41  (97.6%) patients. In one patient with superficial basalioma clinical cure was achieved after the second cycle of LITT. After epithelization of the tumor site, excellent and good clinical result was observed in 15 (35.7%) and 22 (52.5%) patients, respectively (satisfactory results were found only in 5 cases (11,8%), p<0,05). According to the Likert scale scores, 40  patients (95.2%) were very satisfied and 2  patients (4.8%) were satisfied with the treatment. Conclusion: Adding Egallohit after LITT in patients with basaliomas resulted in reduction of connective tissue growth in the lesions, promoted scar tissue resolution and surface smoothening (especially during scar formation), inhibited hyperemia and pigmentation and improved elasticity and displaceability of surrounding tissues.
Almanac of Clinical Medicine. 2014;(34):60-64
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DERMOSCOPIC DIAGNOSTIC CRITERIA IN DIFFERENT MORPHOLOGICAL TYPES OF BASALIOMA

Khlebnikova A.N., Novoselova N.V.

Abstract

Background: Basal cell carcinoma of the skin (BCC, basalioma) is one of the most common malignant skin tumors. Dermoscopy is the most available today method of non-invasive diagnosis of skin tumors. Though, its usability is limited due to absence of prognostic dermoscopic criteria associated with different morphological variants of basalioma. Aim: To define dermoscopic features of different histological types of BCC. Materials and methods: 35 biopsy specimens from BCC lesions were evaluated. After clinical examination, superficial basalioma was diagnosed in 18 patients and nodular form in 17 patients. Results: Vascular structures were detected in 100% of cases. In patients with superficial multicentric type of basalioma, presence of all vascular types was a significant prognostic factor; predictive values of point- and spike-shaped vessels were 100 and 71.4%, respectively. Absence of point-shaped vessels and presence of other vascular types were associated with the prognosis of nodular basalioma. In patients with infiltrative type of basalioma, dendriform, tortuous and linear vessels in combination with short tiny teleangiectases and absence of spike-, comma-, point- or glome-like vessels had positive prognostic value. In patients with superficial multicentric and nodular types of basalioma, homogenous white and rose zones were most prevalent: in 53.8 and 57.1% of cases, respectively. In infiltrative type, this feature was typically absent (р<0,04). Conclusion: Different morphological types of basaliomas are characterized by different dermoscopic features. Vascular structures are most strongly associated with the prognosis of the disease.
Almanac of Clinical Medicine. 2014;(34):65-70
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IMMUNOTHERAPEUTIC METHOD FOR TREATMENT OF KAPOSI’S SARCOMA

Kartashova M.G., Kil’dyushevskiy A.V., Molochkov A.V.

Abstract

Aim: To develop a new treatment method for Kaposi’s sarcoma. Materials and methods: 20 patients with Kaposi’s sarcoma (15 patients with idiopathic and 5 patients with immunosuppressive type) underwent clinical and immunological examination before and after translational cell immunotherapy. Method of translational cell immunotherapy involved administration of photosensitizer Ammifurin 0.6  mg/kg 1.5–2  hours before the procedure of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. After separation of cells from 2000  ml blood, mean cell count was 6.2±0.8×10⁹ cells per 100  ml plasma. 100  ml of normal saline was added to provide hematocrit value 2% or less. Cell suspension was exposed to UVA-radiation (λ=320–400 nm) using blood irradiator Julia (10–15 ml/min) during 90 minutes. Then, 200 ml of nutrient buffer solution Intersol (Baxter) for long-term storage of platelets was added to cell suspension; reaction mixture was incubated at 37 °С during 18–20 hours under constant stirring in thrombomixer, then re-infused during 30 minutes. Results: Analysis of immunological phenotype of patients with Kaposi’s sarcoma demonstrated alterations predominantly in cell immunity. After the cycle of translational cell therapy, dramatic clinical improvement was observed in all patients. After 1–5  years of follow-up, remission duration was 5 months – 4 years (mean value – 14.8 months). Conclusion: Translational cell immunotherapy produced good clinical effects and slowed down disease progression. Thus, it can be recommended for adjuvant or alternative treatment of Kaposi’s sarcoma.
Almanac of Clinical Medicine. 2014;(34):71-77
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NICOTINAMIDE IN COMPLEX TREATMENT OF LARGE-PLAQUE PARAPSORIASIS AND EARLY STAGES OF MALIGNANT T-CELL SKIN LYMPHOMAS

Khamaganova I.V., Pomerantsev O.N., Novozhilova O.L., Mitroshina V.P., Shvets O.I.

Abstract

Aim: To assess clinical efficacy of nicotinamide in 2 the treatment of patients with early stages of malignant T-cell skin lymphomas and large-plaque parapsoriasis. Materials and methods: 12 patients with erythematous stage of mycosis fungoides and 14 patients with large-plaque parapsoriasis were treated by nicotinamide 15 mg twice daily during 2 weeks. Treatment cycles were repeated 4–5 times per year; topical therapy was also administrated. Results: Nicotinamide demonstrated high therapeutic effect and good tolerability in patients with early stage of mycosis fungoides and large-plaque parapsoriasis. Stable remission was achieved in 1  woman with malignant T-cell lymphoma and 12  patients with large-plaque parapsoriasis; significant clinical improvement was shown in 8 and 12 patients, respectively. Conclusion: Thus, nicotinamide is recommended for comprehensive treatment of large-plaque parapsoriasis and early stages of mycosis fungoides.
Almanac of Clinical Medicine. 2014;(34):78-80
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EXTRA-CORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF LYMPHOMATOID PAPULOSIS AND FOLLICULOTROPIC MYCOSIS FUNGOIDES: CASE REPORTS

Kil’dyushevskiy A.V., Karzanov O.V., Aleksandrovа N.M.

Abstract

Aim: To assess clinical efficacy of extra-corporeal photochemotherapy (EPCT) in the treatment of rare lymphomas  – lymphomatoid papulosis and folliculotropic mycosis fungoides. Materials and methods: This is a presentation of two cases of lymphomatoid papulosis and folliculotropic mycosis fungoides treated with EPCT with duration of follow-up 9 and 12  years. Extracorporeal photochemotherapy involved administration of 8-methoxypsoralen 0.6 mg/kg 1.5–2 hours before the initiation of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. Cell suspension was exposed to UVA-radiation (λ=320–400  nm) using blood irradiator Julia (10–15 ml/min) during 30 minutes then re-infused. In total, 4 procedures were conducted every other day. Results: Both patients demonstrated positive effect involving regression of the rashes after 3 EPCT cycles. Subsequently, the patients received maintenance EPCT 2–3 times a year. Conclusion: High clinical efficacy of EPCT was demonstrated in 2  patients with lymphomatoid papulosis and folliculotropic mycosis fungoides after 9 and 12 years of follow-up.
Almanac of Clinical Medicine. 2014;(34):81-84
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COSMETOLOGY

LIPOSOMAL COSMETICS AICIDA IN THE TREATMENT OF CHRONIC DERMATOSES (A REVIEW)

Molochkov A.V., Khlebnikova A.N.

Abstract

The article reviews literature data on the efficacy of liposomal cosmetics Aicida in the treatment of chronic dermatoses. This product line is Antiseptic Dorogov’s Stimulator (ASD)-based which has been applied in dermatology during 60 years. Modern liposomal technologies have been used in the development of new cosmetic bases to ensure conformance to current standards. Gelcream for sensitive face and body skin, hand gelcream and dry scalp balsam have been successfully used in the treatment of psoriasis. Gel-cream for hands and sensitive face and body skin has demonstrated good efficacy in the treatment of hands eczema and mild and moderate atopic dermatitis. Using cosmetic line Aicida for basic care in patients with remission of chronic dermatoses ensures good skin status and promotes longer remissions.
Almanac of Clinical Medicine. 2014;(34):85-90
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HOMEOPATHIC MEDICINE IN THE TREATMENT OF ACNE

Kolyadenko V.G., Golovchenko D.Y., Popova L.I.

Abstract

Background: Systemic medicines for the treatment of acne (antibiotics, retinoids, oral contraceptives) frequently induce adverse events which result in dose reduction or treatment discontinuation and negatively influence treatment efficacy. Chronic application of topical agents may be associated with skin irritation and dermatitis. Thus, there is a constant need for new agents and therapeutic methods producing safe and effective treatment of this commonest skin disorder. Aim: To assess efficacy and tolerability of homeopathic medicine Loma Lux Acnemol in tablets. Materials and methods: 60 patients (age 18–35 years old) with mild and moderate acne were equally divided into two treatment and control groups. During 6 weeks, all patients received routine therapy of acne (sulphur preparations, vitamins, health-promoting therapies); in the treatment group, patients also received homeopathic medicine Loma Lux Acnemol (the dose depended on the body mass). Treatment efficacy criteria included severity of lesion hyperemia, regression of papular rash, absence of new elements and intensity of pain or burning sensation of the skin. Results: Adding Loma Lux Acnemol resulted in significantly better treatment efficacy compared to the routine therapy only: after 6 weeks, clinical improvement was registered in 16 (53.3%) and 6 (20%) patients in the treatment and control groups, respectively; clinical remission was induced in 5 (16.6%) and 7 (23.3%) patients, respectively; evident clinical improvement was absent in 9 (30%) and 12 (40%) cases, respectively. All patients treated with Loma Lux Acnemol reported good tolerability of the medicine; no adverse effects were observed. Conclusion: Homeopathic medicine Loma Lux Acnemol may be recommended for the treatment of mild and moderate acne in young patients.
Almanac of Clinical Medicine. 2014;(34):914-95
pages 914-95 views

VENEREOLOGY

PERIANAL CONDYLOMAS: CLINICAL SYMPTOMS, DIAGNOSIS AND TREATMENT OPPORTUNITIES

Antipova E.V., Filippenko V.A., Kuznetsova E.V., Fabrikova E.A., Davidovich D.L., Solomka A.Y.

Abstract

The article discusses current data on the prevalence and clinical manifestations of papyllomavirus infection. Burning issues of diagnosis and treatment are delineated. Experience-based recommendations on the diagnosis and treatment of papyllomavirus infection are presented.
Almanac of Clinical Medicine. 2014;(34):96-99
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INDINOL FORTO AND EGALLOHIT IN THE TREATMENT OF CONDYLOMA ACUMINATE AND GIANT CONDYLOMA

Molochkov V.A., Molochkova Y.V.

Abstract

Genital papilloma virus is one of the commonest sexually transmitted disease. Its treatment is still under development and relapses are frequent. The article presents the results of the study of indolecarbinol (Indinol Forto) for the prevention of recurrent genital warts in 75  patients with genital or anal condyloma acuminata, BuschkeLowenstein tumor and bowenoid papulosis, after photodynamic therapy (PDT), cryodestruction, electrocoagulation or Mardil Selen application. Seven patients with Buschke-Lowenstein tumor underwent PDT with subsequent application of Egallohit gel on the lesions. Indolecarbinol 400 mg daily was prescribed for 3 months in combination with alpha2b-interferon (Viferon) 1 million IU daily during 1–3 months. No recurrences were observed during follow-up (mean follow-up duration was 3.9±2.7 years, from 5  months to 9  years). In patients with BuschkeLowenstein tumor, PDT with subsequent Egallohit application resulted in the formation of thin and cosmetically acceptable zones of atrophic scars. The article includes three case reports of patients with Buschke-Lowenstein tumor.
Almanac of Clinical Medicine. 2014;(34):100-105
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PHOTOPHERESIS IN THE COMPREHENSIVE TREATMENT OF UROGENITAL REACTIVE ARTHRITIS (REITER’S DISEASE)

Petrova M.S., Kil’dyushevskiy A.V., Molochkova Y.V.

Abstract

The article reports successful use of extracorporeal photochemotherapy (photopheresis) in the comprehensive treatment of 9 patients with urogenital reactive arthritis (Reiter’s disease).
Almanac of Clinical Medicine. 2014;(34):106-107
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SILDENAFIL AND CHRONIC PROSTATITIS

Molochkov V.A.

Abstract

Prostate stands in close anatomical and functional relations with urethra, genital glands and other pelvic organs. Inflammatory process in prostate is almost universally associated with inflammation in other genitourinary organs as well as sexual dysfunction, abnormal spermogram, psycho-emotional disorders and, in elderly men, with benign prostatic hyperplasia. Sildenafil (phosphodiesterase-5 inhibitor) is effective in the treatment of erectile dysfunction, testicular insufficiency and depression which may persist after the standard therapy of chronic prostatitis and is recommended as add-on to rehabilitation procedures after chronic prostatitis therapy.

Almanac of Clinical Medicine. 2014;(34):108-111
pages 108-111 views

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